Secretion-factor-dependent mechanisms regulating transposable elements in the early mouse embryo
| Project/Area Number |
16K15054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | レトロトランスポゾン / 転移因子 / インターロイキン / 全能性 / 多能性 / エピジェネティクス |
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| Outline of Final Research Achievements |
Transposable elements are dispersed throughout the mammalian genome. Appropriate regulation of these elements is indispensable for the survival of the embryos/fetuses. In this study, using the mouse system, I found that the application of the IL17, one of the interleukin family members, to the cells could repress their transcription. Furthermore, I identified an IL17D receptor responsible for the immobilization of the transposable elements and the downstream signaling pathways as well. In the absence of IL17D signaling pathways, apoptosis signals are concomitantly upregulated, thereby cells with low quality are removed for supporting the proper embryonic development.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.2017
Author(s)
Sanosaka T, Imamura T, Hamazaki N, Chai M, Igarashi K, Ideta-Otsuka M, Miura F, Ito T, Fujii N, Ikeo K, Nakashima K
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Journal Title
Cell Rep
Volume: 20
Issue: 12
Pages: 2992-3003
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Reconstitution in vitro of the entire cycle of the mouse female germ line.2016
Author(s)
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K
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Journal Title
Nature
Volume: 539
Issue: 7628
Pages: 299-303
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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