| Project/Area Number |
16K15054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | レトロトランスポゾン / 転移因子 / インターロイキン / 全能性 / 多能性 / エピジェネティクス |
|---|
| Outline of Final Research Achievements |
Transposable elements are dispersed throughout the mammalian genome. Appropriate regulation of these elements is indispensable for the survival of the embryos/fetuses. In this study, using the mouse system, I found that the application of the IL17, one of the interleukin family members, to the cells could repress their transcription. Furthermore, I identified an IL17D receptor responsible for the immobilization of the transposable elements and the downstream signaling pathways as well. In the absence of IL17D signaling pathways, apoptosis signals are concomitantly upregulated, thereby cells with low quality are removed for supporting the proper embryonic development.
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