| Project/Area Number |
16K15055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エピジェネティクス / TERT遺伝子 / 細胞不死化機構 |
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| Outline of Final Research Achievements |
Telomerase reverse transcriptase (TERT) is an important molecule that supports high self-proliferative capacity in stem cells. However, epigenetic regulation of tissue-specific expression for the human TERT gene is unknown. In this study, we identified the differentially DNA methylated region of the TERT gene (TERT- DMR), of which hypermethylation enhanced TERT expression. Furthermore, H3K4me3 modification was recognized in human iPS cells, onthe other hand, H3K27me3 modification and HP - 1α binding were significantly recognized in somatic cells. We showed here a new epigenetic mechanism that DNA hypermethylation acts on gene expression.
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