• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the bone metabolism failure in the aging animals and establishment of the preventive maintenance plan based on the animal welfare

Research Project

Project/Area Number 16K15057
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionThe University of Tokyo

Principal Investigator

Endo Hideki  東京大学, 総合研究博物館, 教授 (30249908)

Co-Investigator(Kenkyū-buntansha) 村田 浩一  日本大学, 生物資源科学部, 教授 (00339285)
鯉江 洋  日本大学, 生物資源科学部, 教授 (20267040)
中山 裕之  東京大学, 大学院農学生命科学研究科(農学部), 教授 (40155891)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords高齢 / 病理 / 飼育動物 / 動物園 / 骨増生 / 骨変形 / 動物福祉 / QOL / 超高齢動物 / 病理学 / 骨格 / 水族館 / 野生動物 / 骨形質 / 機能形態学 / 骨病理学 / 飼育技術
Outline of Final Research Achievements

Skeletons of aging animals were collected, macro morphological changes of bones were investigated, and three dimensional images were successfully reconstructed. In Asian elephant, hippopotamus, white rhinoceros and giraffe, macro morphological anomalies in the spine, limbs, skull were detected and a fundamental theory of bone aging was constructed. In old Asian elephants, we discussed the problems of the jaw and molar tooth using three dimensional images. In medium-sized animals we observed abnormalities in the jaw and facial function, and also in birds and reptiles, we could establish the theory on the aging and morphological changes along with the physiological background. The results succeeded in greatly expanding the opportunities for collecting basic biological and pathological data on maintained animals, in addition to the direct research of aging animals. Based on these results, we also could develop the new opinion of the animal welfare towards the zoos and aquaria.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (44 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (27 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 27 results,  Open Access: 23 results,  Acknowledgement Compliant: 5 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (2 results) Remarks (5 results)

  • [Int'l Joint Research] カセサート大学/タイ国立公園局・天然資源環境省(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ベトナム生態生物資源研究所(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Geographical variation in the skeletal morphology of Red Jungle Fowl2017

    • Author(s)
      H. Endo, N. Tsunekawa, M. Sonoe, T. Sasaki, H. Ogawa, T. Amano, N. T. Son, V. Phimphachanhvongsod, K. Kudo, T. Yonezawa & F. Akishinonomiya
    • Journal Title

      British Poultry Science

      Volume: 印刷中 Issue: 4 Pages: 348-357

    • DOI

      10.1080/00071668.2017.1311008

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Morphological variation in brain through domestication of fowl2017

    • Author(s)
      Kawabe Soichiro、Tsunekawa Naoki、Kudo Kohei、Tirawattanawanich Chanin、Akishinonomiya Fumihito、Endo Hideki
    • Journal Title

      Journal of Anatomy

      Volume: 231 Issue: 2 Pages: 287-297

    • DOI

      10.1111/joa.12623

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macroscopic and CT examinations of the mastication mechanism in the southern tamandua.2017

    • Author(s)
      Endo, H., Ito, K., Watabe, H., Son, N.T., Koyabu, D.
    • Journal Title

      Mammal Study

      Volume: 42 Issue: 2 Pages: 89-96

    • DOI

      10.3106/041.042.0203

    • NAID

      40021221598

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Into the dark: patterns of middle ear adaptations in subterranean eulipotyphlan mammals2017

    • Author(s)
      Koyabu Daisuke、Hosojima Misato、Endo Hideki
    • Journal Title

      Royal Society Open Science

      Volume: 4 Issue: 9 Pages: 170608-170608

    • DOI

      10.1098/rsos.170608

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Growth Pattern and Functional Morphology of the Cervical Vertebrae in the Gerenuk (Litocranius walleri): The Evolution of Neck Elongation in Antilopini (Bovidae, Artiodactyla)2017

    • Author(s)
      Gunji Megu、Endo Hideki
    • Journal Title

      Journal of Mammalian Evolution

      Volume: - Issue: 2 Pages: 225-235

    • DOI

      10.1007/s10914-017-9396-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (<i>Macaca fascicularis</i>)2017

    • Author(s)
      hunya Nakayama, Hiroshi Koie, Kiichi Kanayama, Yuko Katakai, Yasuyo Ito-Fujishiro, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 5 Pages: 881-888

    • DOI

      10.1292/jvms.16-0638

    • NAID

      130007331475

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adenocarcinoma of Barrett’s esophagus in a dog2017

    • Author(s)
      James K. Chambers, Saito Tsubasa, Fukushima Kenjiro, Kakuta Shigeru, Nakayama Jun, Ohno Koichi, Tsujimoto Hajime, Nakayama Hiroyuki, Uchida Kazuyuki
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 30 Issue: 3 Pages: 239-243

    • DOI

      10.1293/tox.2017-0009

    • NAID

      130005815283

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variations in Histiocytic Differentiation of Cell Lines From Canine Cerebral and Articular Histiocytic Sarcomas.2017

    • Author(s)
      Thongtharb A, Uchida K, Chambers JK, Nakayama H.
    • Journal Title

      Veterinary Pathology

      Volume: In press Issue: 3 Pages: 395-404

    • DOI

      10.1177/0300985817690211

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues.2017

    • Author(s)
      Shiga T, Uchida K, Chambers JK, Nakayama H.
    • Journal Title

      J Vet Diagn Invest.

      Volume: 29(6): Issue: 6 Pages: 805-813

    • DOI

      10.1177/1040638717715287

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit2017

    • Author(s)
      Kok M.K.、Chambers J.K.、Ushio N.、Watamori A.、Miwa Y.、Nakayama H.、Uchida K.
    • Journal Title

      Journal of Comparative Pathology

      Volume: 157 Issue: 2-3 Pages: 126-135

    • DOI

      10.1016/j.jcpa.2017.06.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IgA Antibodies Against Gliadin and Tissue Transglutaminase in Dogs With Chronic Enteritis and Intestinal T-Cell Lymphoma2017

    • Author(s)
      Matsumoto, I., Uchida, K., Nakashima, K., Hiyoshi, S., Chambers, J.K., Tsujimoto, H. and Nakayama, H.
    • Journal Title

      Veterinary Pathology

      Volume: 55 Issue: 1 Pages: 98-107

    • DOI

      10.1177/0300985817690212

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of <i>Streptococcus gallolyticus</i> with very high degradability of condensed tannins from feces of the wild Japanese rock ptarmigans on Mt. Tateyama2017

    • Author(s)
      Tsuchida Sayaka, Murata Koichi, Ohkuma Moriya, Ushida Kazunari
    • Journal Title

      The Journal of General and Applied Microbiology

      Volume: 63 Issue: 3 Pages: 195-198

    • DOI

      10.2323/jgam.2016.09.003

    • NAID

      130005745311

    • ISSN
      0022-1260, 1349-8037
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of avian haemosporidia among injured wild birds in Tokyo and environs, Japan2017

    • Author(s)
      Inumaru Mizue、Murata Koichi、Sato Yukita
    • Journal Title

      International Journal for Parasitology

      Volume: 6 Issue: 3 Pages: 299-309

    • DOI

      10.1016/j.ijppaw.2017.09.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Functional Morphology of the Skeletal Forelimb, Pectoral Girdle, and Sternum in Japanese Native Domestic Fowls2017

    • Author(s)
      Kudo, K., Tsunekawa, N., Ogawa, H. and Endo, H.
    • Journal Title

      The Journal of Poultry Science

      Volume: 54 Issue: 1 Pages: 47-57

    • DOI

      10.2141/jpsa.0160060

    • NAID

      130005300420

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Musculoskeletal System of Huge Tarsometatarsal Region in the Dong Tao Fowls from North Vietnam2017

    • Author(s)
      Endo, H., Tsunekawa, N., Kudo, K., Hayashi, Y., Ikeya, K., Nguyen, T. S. and Akishinonomiya, F.
    • Journal Title

      The Journal of Poultry Science

      Volume: 54 Issue: 1 Pages: 58-65

    • DOI

      10.2141/jpsa.0160074

    • NAID

      130005300335

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phylogenomics and morphology of extinct paleognaths reveal the origin and evolution of the ratites2017

    • Author(s)
      Takahiro Yonezawa, Takahiro Segawa, Hiroshi Mori, Paula F. Campos, Yuichi Hongoh et al.,
    • Journal Title

      Current Biology

      Volume: 27 Issue: 1 Pages: 68-77

    • DOI

      10.1016/j.cub.2016.10.029

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mobility of the forearm in the raccoon (<i>Procyon lotor</i>), raccoon dog (<i>Nyctereutes procyonoides</i>) and red panda (<i>Ailurus fulgens</i>)2017

    • Author(s)
      Kamioka, M., Sasaki, M., Yamada, K., Endo, H., Oishi, M., Yuhara, K., Tomikawa, S., Sugimoto, M., Oshida, T., Kondoh, D. and Kitamura, N.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 1 Pages: 224-229

    • DOI

      10.1292/jvms.16-0241

    • NAID

      130005296372

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional cervicothoracic boundary modified by anatomical shifts in the neck of giraffe.2016

    • Author(s)
      Gunji, M. and Endo, H.
    • Journal Title

      Royal Society Open Science

      Volume: 3 Issue: 2 Pages: 150604-150604

    • DOI

      10.1098/rsos.150604

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bats (Mammalia: Chiroptera) of the southeastern Truong Son Mountain, Quang Ngai province, Vietnam.2016

    • Author(s)
      Nguyen, T. S., O’shea, T. J., Gore, J. A., Csorba, G., Vuong, T. T., Oshida, T., Endo, H. and Motokawa, M.
    • Journal Title

      Journal of Threatened Taxa

      Volume: 8 Pages: 8953-8969

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Compartive study of physiological cross-sectional area of masticatory muscles among species of Carnivora.2016

    • Author(s)
      Ito, K. and Endo, H.
    • Journal Title

      Mammal Study

      Volume: 41 Issue: 4 Pages: 181-190

    • DOI

      10.3106/041.041.0403

    • NAID

      40021059506

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Migratory ability of gonadal germ cells (GGCs) isolated from <i>Ciconia boyciana</i> and <i>Geronticus eremita</i> embryos into the gonad of developing chicken embryos2016

    • Author(s)
      Nakajima Y, Fukuda H, Onuma M, Murata K, Ueda M, Sunaga E, Shiraishi T, Tajima A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 6 Pages: 1055-1058

    • DOI

      10.1292/jvms.15-0664

    • NAID

      130005159661

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators.2016

    • Author(s)
      Fukuda T, Iino Y, Eitsuka T, Onuma M, Katayama M, Murata K, Inoue-Murayama M, Hara K, Isogai E, Kiyono T
    • Journal Title

      Cytotechnology

      Volume: 68 Issue: 5 Pages: 1937-1947

    • DOI

      10.1007/s10616-016-0004-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians.2016

    • Author(s)
      Kobayashi Y, Horie M, Nakano A, Murata K, Itou T, Suzuki Y.
    • Journal Title

      PLoS Pathog.

      Volume: 12 Issue: 8 Pages: e1005785-e1005785

    • DOI

      10.1371/journal.ppat.1005785

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diversity of MHC class I alleles in Spheniscus humboldti.2016

    • Author(s)
      Kikkawa, E., Tanaka, M., Naruse, T. K., Tsuda, T. T., Tsuda, M., Murata, K. and Kimura, A.
    • Journal Title

      Immunogenetics

      Volume: 69 Issue: 2 Pages: 113-124

    • DOI

      10.1007/s00251-016-0951-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathology of the aging brain in domestic and laboratory animals, and animal models of humen neurodegenerative diseases.2016

    • Author(s)
      Youssef, S. A., Capucchio, M. T., Rofina, J. E., Chambers, J. K., Uchida, K., Nakayama, H. and Head, E.
    • Journal Title

      Veterinary Pathology

      Volume: 53 Issue: 2 Pages: 327-348

    • DOI

      10.1177/0300985815623997

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tracking cells implanted into cynomolgus monkeys (<i>Macaca fascicularis</i>) using MRI2016

    • Author(s)
      Fujishiro Y, Koie H, Shibata H, Okabayashi S, Katakai Y, Ohno C, Kanayama K, Yasutomi Y, Ageyama N.
    • Journal Title

      Experimental Animals

      Volume: 65 Issue: 3 Pages: 311-318

    • DOI

      10.1538/expanim.15-0125

    • NAID

      130006882369

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analysis of the breast milk of giant pandas (<i>Ailuropoda melanoleuca</i>) and the preparation of substitutes2016

    • Author(s)
      Zhang, Z., Hou, R., Lan, J., Wang, H., Kurokawa, H., Takatsu, Z., Kobayashi, T., Koie, H., Kamata, H., Kanayama, K. and Watanabe, T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 5 Pages: 747-754

    • DOI

      10.1292/jvms.15-0677

    • NAID

      130005154289

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 伴侶のコントラスト2018

    • Author(s)
      遠藤秀紀
    • Organizer
      日本美術解剖学会2018年大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 頭骨形態を指標とした束柱類(哺乳類: アフリカ獣類)の水頭骨形態を指標と した束柱類(哺乳類:アフリカ獣類)の水棲適応の定量的解析―Paleoparadoxia 梁川標本を例に―2017

    • Author(s)
      松井久美子・河部壮一郎・遠藤秀紀・對比地孝亘・甲能直樹
    • Organizer
      日本古生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comparative three-dimensional CT image analysis of the mastication system in the giant anteater and southern tamandua2017

    • Author(s)
      Hideki Endo, Kohei Kudo, Junpei Kimura
    • Organizer
      12 th International Mammalogical Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動物園内外の情勢変化と研究の未来2017

    • Author(s)
      遠藤秀紀
    • Organizer
      第23回日本野生動物医学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 台湾左鎮から産出した大型ワニ類の分類学的再検討2017

    • Author(s)
      武川 愛, 青木良輔, 平山 廉, 吉田将崇, 昆 彭生, 遠藤秀紀
    • Organizer
      日本古生物学会
    • Place of Presentation
      早稲田大学(東京都新宿区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 食肉類における咀嚼筋の比較機能形態学的検討2016

    • Author(s)
      伊藤 海, 遠藤秀紀
    • Organizer
      日本哺乳類学会2016年度大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] ゲレヌク(Litocranius walleri)における頸椎の形態と成長様式2016

    • Author(s)
      郡司芽久, 遠藤秀紀
    • Organizer
      日本哺乳類学会2016年度大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 日本鶏における後肢、後肢帯、腰仙骨の機能形態学的特徴と育種動機との関係について2016

    • Author(s)
      工藤光平, 遠藤秀紀
    • Organizer
      日本家禽学会第120回大会
    • Place of Presentation
      静岡県総合研修所もくせい会館(静岡県静岡市)
    • Related Report
      2016 Research-status Report
  • [Book] 有袋類学2018

    • Author(s)
      遠藤 秀紀
    • Total Pages
      258
    • Publisher
      東京大学出版会
    • ISBN
      9784130602549
    • Related Report
      2017 Annual Research Report
  • [Book] 東京大学総合研究博物館所蔵 鶏骨格標本および剥製標本の基礎資料集2016

    • Author(s)
      工藤光平, 遠藤秀紀
    • Total Pages
      254
    • Publisher
      東京大学総合研究博物館
    • Related Report
      2016 Research-status Report
  • [Remarks] Laboratory of Dead Body Science

    • URL

      http://www.um.u-tokyo.ac.jp/people/faculty_endo.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学総合研究博物館 遺体科学研究室

    • URL

      http://www.um.u-tokyo.ac.jp/endo/

    • Related Report
      2016 Research-status Report
  • [Remarks] 日本大学生物資源科学部動物資源科学科 野生動物学研究室

    • URL

      http://hp.brs.nihon-u.ac.jp/~wildlife/

    • Related Report
      2016 Research-status Report
  • [Remarks] 東京大学大学院農学生命科学研究科 獣医病理学研究室

    • URL

      http://www.vm.a.u-tokyo.ac.jp/byouri/

    • Related Report
      2016 Research-status Report
  • [Remarks] 日本大学生物資源科学部獣医学科獣医生理学研究室

    • URL

      http://hp.brs.nihon-u.ac.jp/~vetphys/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi