Analysis of the bone metabolism failure in the aging animals and establishment of the preventive maintenance plan based on the animal welfare
Project/Area Number |
16K15057
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Integrative animal science
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Research Institution | The University of Tokyo |
Principal Investigator |
Endo Hideki 東京大学, 総合研究博物館, 教授 (30249908)
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Co-Investigator(Kenkyū-buntansha) |
村田 浩一 日本大学, 生物資源科学部, 教授 (00339285)
鯉江 洋 日本大学, 生物資源科学部, 教授 (20267040)
中山 裕之 東京大学, 大学院農学生命科学研究科(農学部), 教授 (40155891)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 高齢 / 病理 / 飼育動物 / 動物園 / 骨増生 / 骨変形 / 動物福祉 / QOL / 超高齢動物 / 病理学 / 骨格 / 水族館 / 野生動物 / 骨形質 / 機能形態学 / 骨病理学 / 飼育技術 |
Outline of Final Research Achievements |
Skeletons of aging animals were collected, macro morphological changes of bones were investigated, and three dimensional images were successfully reconstructed. In Asian elephant, hippopotamus, white rhinoceros and giraffe, macro morphological anomalies in the spine, limbs, skull were detected and a fundamental theory of bone aging was constructed. In old Asian elephants, we discussed the problems of the jaw and molar tooth using three dimensional images. In medium-sized animals we observed abnormalities in the jaw and facial function, and also in birds and reptiles, we could establish the theory on the aging and morphological changes along with the physiological background. The results succeeded in greatly expanding the opportunities for collecting basic biological and pathological data on maintained animals, in addition to the direct research of aging animals. Based on these results, we also could develop the new opinion of the animal welfare towards the zoos and aquaria.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Adenocarcinoma of Barrett’s esophagus in a dog2017
Author(s)
James K. Chambers, Saito Tsubasa, Fukushima Kenjiro, Kakuta Shigeru, Nakayama Jun, Ohno Koichi, Tsujimoto Hajime, Nakayama Hiroyuki, Uchida Kazuyuki
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Journal Title
J Toxicol Pathol
Volume: 30
Issue: 3
Pages: 239-243
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IgA Antibodies Against Gliadin and Tissue Transglutaminase in Dogs With Chronic Enteritis and Intestinal T-Cell Lymphoma2017
Author(s)
Matsumoto, I., Uchida, K., Nakashima, K., Hiyoshi, S., Chambers, J.K., Tsujimoto, H. and Nakayama, H.
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Journal Title
Veterinary Pathology
Volume: 55
Pages: 98-107
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Diversity of MHC class I alleles in Spheniscus humboldti2017
Author(s)
Kikkawa, E., Tanaka, M., Naruse, T. K., Tsuda, T. T., Tsuda, M., Murata, K. and Kimura, A.
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Journal Title
Immunogenetics
Volume: 69
Pages: 113-124
DOI
Related Report
Peer Reviewed
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[Journal Article] Phylogenomics and Morphology of Extinct Paleognaths Reveal the Origin and Evolution of the Ratites.2017
Author(s)
Yonezawa T, Segawa T, Mori H, Campos PF, Hongoh Y, Endo H, Akiyoshi A, Manabe M, Kohno N, Nishida S, Wu J, Jin H, Kishino H, Kurokawa K, Yoshifumi N, Tanabe H, Mukoyama H, Yoshida K, Rasoamiaramanana A, Yamagishi S, Hayashi Y, Yoshida A, Koike H, Akishinonomiya F, Willerslev E, Hasegawa M.
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Journal Title
Current Biology
Volume: 27
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mobility of the forearm in the raccoon (Procyon lotor), raccoon dog (Nyctereutes procyonoides) and red panda (Ailurus fulgens)2017
Author(s)
Kamioka M, Sasaki M, Yamada K, Endo H, Oishi M, Yuhara K, Tomikawa S, Sugimoto M, Oshida T, Kondoh D, Kitamura N
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Journal Title
J. Vet. Med. Sci.
Volume: 79
Issue: 1
Pages: 224-229
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bats (Mammalia: Chiroptera) of the southeastern Truong Son Mountain, Quang Ngai province, Vietnam.2016
Author(s)
Nguyen, T. S., O’shea, T. J., Gore, J. A., Csorba, G., Vuong, T. T., Oshida, T., Endo, H. and Motokawa, M.
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Journal Title
Journal of Threatened Taxa
Volume: 8
Pages: 8953-8969
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators.2016
Author(s)
Fukuda T, Iino Y, Eitsuka T, Onuma M, Katayama M, Murata K, Inoue-Murayama M, Hara K, Isogai E, Kiyono T
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Journal Title
Cytotechnology
Volume: 68
Pages: 1937-1947
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pathology of the aging brain in domestic and laboratory animals, and animal models of humen neurodegenerative diseases.2016
Author(s)
Youssef, S. A., Capucchio, M. T., Rofina, J. E., Chambers, J. K., Uchida, K., Nakayama, H. and Head, E.
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Journal Title
Veterinary Pathology
Volume: 53
Pages: 327-348
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Analysis of the breast milk of giant pandas (<i>Ailuropoda melanoleuca</i>) and the preparation of substitutes2016
Author(s)
Zhang, Z., Hou, R., Lan, J., Wang, H., Kurokawa, H., Takatsu, Z., Kobayashi, T., Koie, H., Kamata, H., Kanayama, K. and Watanabe, T.
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Journal Title
J. Vet. Med. Sci.
Volume: 78
Issue: 5
Pages: 747-754
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 有袋類学2018
Author(s)
遠藤 秀紀
Total Pages
258
Publisher
東京大学出版会
Related Report
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