Approach to identify a novel mechanism which modulates vitaminA regulation of adipocyte differentiation
Project/Area Number |
16K15090
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied molecular and cellular biology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ビタミンA / 脂肪細胞 / 細胞外マトリックス / 間葉系幹細胞 / コラーゲン / レチノイン酸 / 分化 |
Outline of Final Research Achievements |
Differentiation of mesenchymal stem cells can be regulated by either retinoic acid, an active metabolite of vitamin A, or stiffness of extracellular matrix (ECM). We previously reported that vinexin, a focal adhesion protein, is involved in sensing ECM stiffness. Given the association of vinexin with retinoic acid receptor, it is hypothesized that retinoic acid and ECM stiffness function cooperatively for regulating the differentiation of mesenchymal stem cells. We examined the effect of vinexin depletion on retinoic acid-induced differentiation. The result partly supports the hypothesis, but also suggests complicated regulation.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation2017
Author(s)
Ichikawa, T., Kita, M., Matsui, T.S., Ichikawa-Nagasato, A., Araki, T., Chiang, S.H., Sezaki, T., Kimura, Y., Ueda, K., Deguchi, S., Saltiel, A.R., Kioka, N.
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Journal Title
Journal of Cell Science
Volume: 130
Pages: 3517-3531
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Lysophosphatidylcholine export by human ABCA72017
Author(s)
Maiko Tomioka, Yoshinobu Toda, Noralyn B. Manucat, Hiroyasu Akatsu, Manabu Fukumoto, Nozomu Kono, Hiroyuki Arai, Noriyuki Kioka, and Kazumitsu Ueda
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Journal Title
Biochimica Biophysica Acta
Volume: 印刷中
Issue: 7
Pages: 658-665
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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