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The search for the novel safeguard system to maintain the telomere length

Research Project

Project/Area Number 16K15094
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied molecular and cellular biology
Research InstitutionKwansei Gakuin University

Principal Investigator

Tanaka Katsunori  関西学院大学, 理工学部, 教授 (60273926)

Co-Investigator(Renkei-kenkyūsha) HAYASHI Aki  関西学院大学, 理工学部, 助教 (80399534)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords染色体 / テロメア / 分裂酵母 / タンパク質翻訳後修飾 / SUMO / Rif1 / SUMO翻訳後修飾 / ゲノム
Outline of Final Research Achievements

Telomeres protect the DNA ends of linear eukaryotic chromosomes from degradation and fusion, as well as ensure complete replication of the DNA terminal through recruitment of telomerase. The regulation of telomerase is a critical area in telomere research in mammals and fission yeast. SUMOylation is known involving in the negative regulation of telomere extension by telomerase. We identified a novel safeguard system to maintain the telomere length. We found that SUMOylation and Rif1 function in a coordinated manner for this safeguard system. Rif1 is a conserved protein that regulates telomere length, replication timing, and repair of double-stranded DNA breaks. Protein phosphatase 1 (PP1) that interacts with Rif1 is known as a key factor for some of Rif1 functions. Furthermore, we have shown the requirement of the PP1 domain of Rif1 for this safeguard system, suggesting that the involvement of dephosphorylation of unknown target protein by Rif1.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] イリノイ大学シカゴ校(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] イリノイ大学シカゴ校/Drexcel大学(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.2017

    • Author(s)
      Noguchi C, Grothusen G, Anandarajan V, Martinez-Lage Garcia M, Terlecky D, Corzo K, Tanaka K, Nakagawa H, Noguchi E.
    • Journal Title

      Cell Cycle

      Volume: 16(1) Issue: 1 Pages: 45-58

    • DOI

      10.1080/15384101.2016.1237326

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 分裂酵母Rif1とSUMO E3リガーゼPli1の相互作用2017

    • Author(s)
      田中克典
    • Organizer
      第35回染色体ワークショップ・第16回核ダイナミクス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分裂酵母Rif1とSUMO E3リガーゼPli1の相互作用2017

    • Author(s)
      田中克典
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] SUMO翻訳後修飾による染色体末端テロメア長制御2016

    • Author(s)
      田中克典
    • Organizer
      第89回 日本生化学会大会
    • Place of Presentation
      東北学院大学(宮城県・仙台市)
    • Year and Date
      2016-09-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Regulation of telomere by SUMOylation in fission yeast2016

    • Author(s)
      Katsunori Tanaka
    • Organizer
      ICY2016(14th International Congress on Yeasts)
    • Place of Presentation
      淡路夢舞台(兵庫県・あわじ市)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 関西学院大学理工学部生命科学科 染色体機能学研究室 ホームページ

    • URL

      http://sci-tech.ksc.kwansei.ac.jp/~tanaka/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 関西学院大学理工学部生命科学科 染色体機能学研究室ホームページ

    • URL

      http://sci-tech.ksc.kwansei.ac.jp/~tanaka/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-06-07  

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