Generation and characterization of highly active intermediates by hypervalent halogen and xenon compounds
| Project/Area Number |
16K15097
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Miyamoto Kazunori 東京大学, 大学院薬学系研究科(薬学部), 講師 (40403696)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 超原子価 / ヨウ素 / 臭素 / 二原子炭素 / キセノン / 脱離能 / ハロゲン / アルキニルカチオン / ジカチオン / 超原子価ハロゲン / オキソニウムジカチオン |
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| Outline of Final Research Achievements |
We successfully generated several super-reactive intermediates such as diatomic carbon, meta-benzene, bis(triflyl)carbene under mild reaction conditions in a flask and discovered their unique physical/chemical characters. The vastly enhanced nucleofugality of hypervalent halogen and xenon leaving groups are responsible for the generation of highly reactive intermediates.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Stille Coupling via C-N Bond Cleavage2016
Author(s)
Dong-Yu Wang, Masatoshi Kawahata, Ze-Kun Yang, Kazunori Miyamoto, Shinsuke Komagawa, Kentaro Yamaguchi, Chao Wang and Masanobu Uchiyama
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Journal Title
Nature. Commun.
Volume: 7
Issue: 1
Pages: 12937-12945
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mechanistic Studies on the Generation and Properties of Superelectrophilic Singlet Carbenes from Bis(perfluoroalkanesulfonyl)bromonium Ylides2016
Author(s)
Miyamoto, Kazunori; Iwasaki, Susumu; Doi, Ryusuke; Ota, Taiga; Kawano, Yufuko; Yamashita, Junpei; Sakai, Yuuta; Tada, Norihiro; Ochiai, Masahito; Hayashi, Satoko; Waro, Nakanishi; Masanobu, Uchiyama
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Journal Title
The Journal of Organic Chemistry
Volume: 81
Issue: 8
Pages: 3188-3198
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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