Development of Novel Synthetic Methods of Fused-heterocyclic Systems by Domino-type Cycloaddition of o-Xylylene Intermediate
| Project/Area Number |
16K15098
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
Matsuya Yuji 富山大学, 大学院医学薬学研究部(薬学), 教授 (50255858)
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| Research Collaborator |
KOHYAMA Aki
KORESAWA Eri
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ドミノ型環化 / ベンゾシクロブテン / ニトロン / ニトロ基 / 熱開裂 / 電子環状反応 / 双極子環化付加 / ペリ環状反応 / オルトキシリレン |
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| Outline of Final Research Achievements |
For the purpose of construction of fused-heterocyclic systems by means of successive electrocyclic reactions of benzocyclobutene derivatives, We successfully synthesized nitron-substituted and nitro-substituted benzocyclobutene derivatives as a potential substrate. Thermal domino-cyclizations were investigated using these derivatives as a substrate, and it was found that the nitron derivatives did not react even under 180°C conditions and the nitro derivatives were hydrolyzed after ring-opening. Thus these compounds were not suitable for the substrates of planned domino-type cycloaddition reactions.
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Report
(3 results)
Research Products
(2 results)
