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Combined cancer immunotherapy of PD-1 antibody and c-di-GMP loaded lipid nanoparticles

Research Project

Project/Area Number 16K15102
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionHokkaido University

Principal Investigator

NAKAMURA Takashi  北海道大学, 薬学研究院, 助教 (20604458)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬物送達学 / がん免疫療法 / 脂質ナノ粒子 / アジュバント / STING / 免疫チェックポイント阻害 / 免疫チェックポイント阻害剤 / がん免疫
Outline of Final Research Achievements

The present study demonstrated that the combination therapy of programmed cell death 1 (PD-1) antibody and lipid nanoparticles (LNP) carrying cyclic di-GMP (c-di-GMP), an agonist for the stimulator of interferon genes pathway, was effective against the PD-1 therapy resistant tumor. Moreover, the dose of PD-1 antibody was reduced by combining the lipid nanoparticles. Thus, the c-di-GMP loaded LNP can be potent candidate for the combination therapy with PD-1 antibody.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Development of a Drug Delivery System for Cancer Immunotherapy2016

    • Author(s)
      Takashi Nakamura
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 136 Issue: 11 Pages: 1477-1484

    • DOI

      10.1248/yakushi.16-00187

    • NAID

      130005267659

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2016-11-01
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 脂質ナノ粒子を基盤としたがん免疫療法のためのナノDDS開発2018

    • Author(s)
      中村孝司
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cancer immunotherapy by STING ligand loaded lipid nanoparticles2017

    • Author(s)
      Naomichi Takahashi, Takashi Nakamura, Yusuke Sato, Mamoru Hyodo, Yoshihiro Hayakawa, Hideyoshi Harashima
    • Organizer
      The 36th Sapporo International Cancer Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STINGリガンド搭載脂質ナノ粒子を用いたがん免疫療法2017

    • Author(s)
      高橋直道、中村孝司、佐藤悠介、兵藤守、早川芳宏、原島秀吉
    • Organizer
      日本薬学会北海道支部第144回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] STINGリガンド搭載ナノDDSを基盤としたがん免疫療法2017

    • Author(s)
      中村孝司、高橋直道、宮部寛子、佐藤悠介、兵藤守、早川芳宏、原島秀吉
    • Organizer
      第21回日本がん免疫学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂質ナノ粒子によるSTING経路活性化を介したがん免疫療法2017

    • Author(s)
      高橋直道、中村孝司、佐藤悠介、兵藤守、早川芳宏、原島秀吉
    • Organizer
      第33会日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] STING ligand loaded lipid nanoparticles enhance cancer immunotherapy2016

    • Author(s)
      Takashi Nakamura, Hiroko Miyabe, Mamoru Hyodo, Yusuke Sato, Yoshihiro Hayakawa, Hideyoshi Harashima
    • Organizer
      3rd International Conference on Biomaterials Science
    • Place of Presentation
      東京大学伊藤国際学術センター(東京都・文京区)
    • Year and Date
      2016-11-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノテクノロジーで制御するがんアジュバントシステムの創製2016

    • Author(s)
      中村孝司
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      長良川国際会議場・岐阜都ホテル(岐阜県・岐阜市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 北海道大学大学院薬学研究院 薬剤分子設計学研究室ホームページ

    • URL

      http://www.pharm.hokudai.ac.jp/yakusetu/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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