Design of functional polymers responsive to tumor microenvironment and their applications for diagnosis and therapy
| Project/Area Number |
16K15104
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 温度応答性ポリマー / がん / pH応答性 / 微小環境 / イメージング / 光線力学治療 / ドラッグデリバリーシステム / 環境応答性高分子 |
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| Outline of Final Research Achievements |
In this study, we synthesized novel poly (N-isopropylacryl amide) (PNIPAAm) derivatives with pH-responsive cleavable groups such as 2-propionic-3-methyl maleic amide(PMM) moiety, thereby exhibiting a great change in lower critical solution temperature (LCST) responding to environmental pH. The PNIPAAm derivatives are completely soluble at physiological pH in the blood compartment (pH 7.4), but change to a hydrophobic nature in response to the low pH environment in the tumor tissue through the cleavage of PMM. As a result, the in vitro and in vivo experiments revealed that the optimized PNIPAAm derivatives showed enhanced cellular uptake under acidic conditions and improved retention in the tumor tissue after the systemic administration to the tumor-bearing mice. These polymers are expected to be applied to molecular imaging and photodynamic therapy (PDT) of malignant tumors.
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound2017
Author(s)
M. Maeda, Y. Muragaki, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki
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Journal Title
Ultrasound Med. Biol.
Volume: 43
Issue: 10
Pages: 2295-2301
DOI
Related Report
Peer Reviewed
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[Journal Article] Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors.2017
Author(s)
P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka,
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Journal Title
J. Control. Release
Volume: 254
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017
Author(s)
M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka
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Journal Title
J. Biomater. Sci. Polym.
Volume: 28
Issue: 10-12
Pages: 1109-1123
DOI
Description
【掲載確定】 in press
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Enhanced Efficacy against Cervical Carcinomas through Polymeric Micelles Physically Incorporating the Proteasome Inhibitor MG132.2016
Author(s)
Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
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Journal Title
Cancer Sci
Volume: in press
Issue: 6
Pages: 773-781
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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