| Project/Area Number |
16K15106
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Saji Hideo 京都大学, 薬学研究科, 教授 (40115853)
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| Co-Investigator(Kenkyū-buntansha) |
小野 正博 京都大学, 薬学研究科, 教授 (80336180)
木村 寛之 京都薬科大学, 薬学部, 准教授 (50437240)
佐野 紘平 京都大学, 薬学研究科(研究院), 助教 (00546476)
渡邊 裕之 京都大学, 薬学研究科, 助教 (40710786)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | PET / 膵β細胞 / 糖尿病 |
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| Outline of Final Research Achievements |
In this study, we designed and synthesized a 68Ga labeled PET probe (68Ga-Df9-Ex(9-39)) targeting GLP-1 receptor for early diagnosis and preemptive medicine of diabetes. 67Ga-Df9-Ex(9-39) was synthesized with high specific radioactivity and radiochemical yield. In addition, it showed the high uptake in normal mouse pancreas and the radioactivity was maintained until 120 min after injection. These results suggested that 68Ga-Df9-Ex(9-39) may be a useful probe for imaging GLP-1 receptors.
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