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Development of PET probes targeting pancreatic b-cells for early diagnosis and preemptive medicine of diabetes.

Research Project

Project/Area Number 16K15106
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionKyoto University

Principal Investigator

Saji Hideo  京都大学, 薬学研究科, 教授 (40115853)

Co-Investigator(Kenkyū-buntansha) 小野 正博  京都大学, 薬学研究科, 教授 (80336180)
木村 寛之  京都薬科大学, 薬学部, 准教授 (50437240)
佐野 紘平  京都大学, 薬学研究科(研究院), 助教 (00546476)
渡邊 裕之  京都大学, 薬学研究科, 助教 (40710786)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsPET / 膵β細胞 / 糖尿病
Outline of Final Research Achievements

In this study, we designed and synthesized a 68Ga labeled PET probe (68Ga-Df9-Ex(9-39)) targeting GLP-1 receptor for early diagnosis and preemptive medicine of diabetes. 67Ga-Df9-Ex(9-39) was synthesized with high specific radioactivity and radiochemical yield. In addition, it showed the high uptake in normal mouse pancreas and the radioactivity was maintained until 120 min after injection. These results suggested that 68Ga-Df9-Ex(9-39) may be a useful probe for imaging GLP-1 receptors.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (1 results)

  • [Journal Article] <i>In Vivo</i> Molecular Imaging2017

    • Author(s)
      Hideo Saji
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 10 Pages: 1605-1615

    • DOI

      10.1248/bpb.b17-00505

    • NAID

      130006110589

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Remarks] 京都大学大学院薬学研究科 病態機能分析学分野

    • URL

      http://www.pharm.kyoto-u.ac.jp/byotai/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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