Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cells

Research Project

Project/Area Number	16K15117
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Biological pharmacy
Research Institution	University of Toyama
Principal Investigator	Hiroaki Sakurai 富山大学, 大学院医学薬学研究部(薬学), 教授 (00345571)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	がん / シグナル伝達 / 代謝 / グルコース / Nrf2 / 細胞 / 糖 / 癌
Outline of Final Research Achievements	We analyzed the effects of Bardoxolone-methyl (BAR), a small molecule activating agents of Nrf2 transcription factor, on cell migration and glucose metabolism in human breast cancer MCF-7 cells. BAR inhibited glycolysis, mitochondrial oxidative phosphorylation, and cell migration via increase in intracellular reactive oxygen species and decrease in glutathione level.

Report

(3 results)