Genetic tools for circuit-based drug discovery
| Project/Area Number |
16K15125
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Shuji 京都大学, 大学院薬学研究科, 教授 (60177516)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルスベクター / セロトニン / 光遺伝学 |
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| Outline of Final Research Achievements |
Neural transmission is achieved through three steps of biological processes. Depolarization and firing at cell somata, propagation of action potential, and release of neurotransmitters from nerve terminals. Different from other types of neurons, serotonin neurons and dopamine neurons release their transmitters from cell somata. However, physiological significance of this type of transmitter release is still unknown. In this research, we established viral-vector based platform for expressing miniSOG, a genetic tool for photo-inducible organelle inactivator, specifically in serotonin neurons.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] High-speed and scalable whole-brain imaging in rodents and primates2017
Author(s)
Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H
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Journal Title
Neuron
Volume: 94
Issue: 6
Pages: 1085-1100
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.2017
Author(s)
Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
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Journal Title
Schizophr Res.
Volume: 181
Pages: 75-82
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ2016
Author(s)
Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
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Journal Title
J. Mol. Psychiatry
Volume: 4
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.2016
Author(s)
Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.
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Journal Title
Behav Brain Res.
Volume: 314
Pages: 477-486
DOI
Related Report
Peer Reviewed / Open Access
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