| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Macrophages play key roles in innate immunity. Ion channels in macrophages modulate membrane potentials and control intracellular calcium signaling to cause immune responses against various types of stimulation. In the present study, we focused on two kinds of potassium channels, TWIK-1 (a member of two pore domain K+ channel family) and Kir2.1 (a member of inwardly rectifying K+ channel family), whose roles in macrophages are unknown. In our study it was indicated that TWIK-1 functions as a non-selective cation channel not a K+ channel and modulates membrane potentials and cytokine production. On the other hands, Kir2.1 may be one of the negative regulators of differentiation into M1 state.
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