Elucidation of pathogenesis of drug-induced immune diseases caused by activation of inflammasome
Project/Area Number |
16K15146
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Environmental and hygienic pharmacy
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 薬剤誘発性免疫疾患 / インフラマソーム / 炎症性サイトカイン / NLRPファミリー分子 / 薬剤副作用 |
Outline of Final Research Achievements |
Drug-induced immune diseases, such as interstitial pneumonia caused by the anticancer drug Gefitinib, are considered to be fatal and severe side effects and important problems, which must be solved in the field of pharmaceutical health science. However, the actual cause of the diseases is not yet well understood. Inflammasomes, intracellular receptors recognizing pathogens and foreign materials, induce inflammation and cell death and have recently been shown to be the cause of various immune diseases. In this study, we revealed that several drugs activate inflammasomes composed of NLRP family molecules, and that drug-induced immune diseases may be partially caused by abnormal promotion of immune response through the activation of inflammasomes.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1 negative regulator PRMT1.2017
Author(s)
Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H., Matsuzawa, A.
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Journal Title
Cell Rep.
Volume: 21
Issue: 9
Pages: 2447-2457
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.2017
Author(s)
Hirata, Y., Takahashi, M., Kudoh, Y., Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., Noguchi, T., Matsuzawa, A.
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Journal Title
J. Biol. Chem.
Volume: 印刷中
Issue: 20
Pages: 8174-8185
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.2017
Author(s)
Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H., Yoshinari, K.
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Journal Title
Arch. Toxicol.
Volume: 印刷中
Issue: 6
Pages: 2365-2374
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1) governs the recruitment of tumor necrosis factor receptor-associated factor 2 (TRAF2) to tumor necrosis factor receptor 1 (TNFR1) signaling complexes.2016
Author(s)
Noguchi, T., Tsuchida, M., Kogue, Y., Spadini, C., Hirata, Y., Matsuzawa, A.
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Journal Title
Int. J. Mol. Sci.
Volume: 17
Issue: 11
Pages: 1869-1869
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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