Structure-toxicity relationship of designer drug having phenethylamine moiety
| Project/Area Number |
16K15147
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOTAKE YAICHIRO 広島大学, 医歯薬保健学研究院(薬), 准教授 (20335649)
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| Co-Investigator(Kenkyū-buntansha) |
太田 茂 広島大学, 医歯薬保健学研究院(薬), 教授 (60160503)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 危険ドラッグ / 構造毒性相関 / フェネチルアミン / トキシコフォア |
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| Outline of Final Research Achievements |
We synthesized candidates of designer drugs having phenethylamine moiety and examined methamphetamine-related in vitro and in vivo activities. As a result, we found the particular compound having strong dopamine uptake inhibitory activity, locomotor activity, and dependency.
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Report
(2 results)
Research Products
(12 results)
