Development of an animal model of Stevens-Johnson syndrome induced by drugs.
Project/Area Number |
16K15154
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | University of Tsukuba |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA NAOYUKI 筑波大学, 医学医療系, 教授 (60231437)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ヒトの薬物動態・代謝予測系 / 皮膚薬剤過敏症 |
Outline of Final Research Achievements |
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening drug adverse effects and are associated with human leukocyte antigen (HLA). Established animal models of Stevens-Johnson syndrome are using graft versus host effects. Thus, it was tried to develop an animal model of Stevens-Johnson syndrome induced by carbamazepine. Stevens-Johnson syndrome was not induced with carbamazepine in the transgenic mouse of HLA-A*31:01, a susceptibility allele for carbamazepine-induced Stevens-Johnson syndrome. The treatment with Poly (I:C) or irradiation did not enhance the development of Stevens-Johnson syndrome in the transgenic mouse of HLA-A*31:01.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population.2018
Author(s)
Oka S, Higuchi T, Furukawa H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Tsuchiya N, Migita K.
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Journal Title
J Hum Genet.
Volume: 印刷中
Issue: 6
Pages: 739-744
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population2018
Author(s)
A Kawasaki, K Yamashita, F Hirano, KE Sada, D Tsukui, Y Kondo, Y Kimura, K Asako, S Kobayashi, H Yamada, H Furukawa, K Nagasaka, T Sugihara, K Yamagata, T Sumida, S Tohma, H Kono, S Ozaki, S Matsuo, H Hashimoto, H Makino, Y Arimura, M Harigai, N Tsuchiya
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Journal Title
Journal of Human Genetics
Volume: 63
Issue: 1
Pages: 55-62
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Incidence and risk factors for infections requiring hospitalization, including pneumocystis pneumonia, in Japanese patients with rheumatoid arthritis.2017
Author(s)
Hashimoto A, Suto S, Horie K, Fukuda H, Nogi S, Iwata K, Tsuno H, Ogihara H, Kawakami M, Komiya A, Furukawa H, Matsui M, Tohma S.
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Journal Title
Int J Rheumatol.
Volume: 2017
Pages: 6730812-6730812
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease.2017
Author(s)
Asano T, Furukawa H, Sato S, Yashiro M, Kobayashi H, Watanabe H, Suzuki E, Ito T, Ubara Y, Kobayashi D, Iwanaga N, Izumi Y, Fujikawa K, Yamasaki S, Nakamura T, Koga T, Shimizu T, Umeda M, Nonaka F, Yasunami M, Ueki Y, Eguchi K, Tsuchiya N, Tohma S, Yoshiura KI, Ohira H, Kawakami A, Migita K.
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Journal Title
Arthritis Res Ther.
Volume: 19
Issue: 1
Pages: 199-199
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.2017
Author(s)
Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, et al.
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Journal Title
Ann Rheum Dis.
Volume: 印刷中
Issue: 6
Pages: 1150-1158
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial.2017
Author(s)
Izumi Y, Akazawa M, Akeda Y, Tohma S, Hirano F, Ideguchi H, Matsumura R, Miyamura T, Mori S, Fukui T, Iwanaga N, Jiuchi Y, Kozuru H, Tsutani H, Saisyo K, Sugiyama T, Suenaga Y, Okada Y, Katayama M, Ichikawa K, Furukawa H, Kawakami K, Oishi K, Migita K.
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Journal Title
Arthritis Res Ther.
Volume: 19
Issue: 1
Pages: 15-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1.2017
Author(s)
Higuchi T, Oka S, Furukawa H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Ohira H, Tsuchiya N, Migita K.
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Journal Title
J Hum Genet.
Volume: in press
Issue: 4
Pages: 481-484
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Independent Association of HLA-G 3’ Untranslated Region 14bp Indel Polymorphism with Systemic Lupus Erythematosus in a Japanese Population: a Case-control Association Study.2016
Author(s)
Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T,Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
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Journal Title
PLoS ONE.
Volume: 11
Issue: 6
Pages: 22-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protective role of HLA-DRB1*13:02 against microscopic polyangiitis and MPO-ANCA positive vasculitis in a Japanese population: a case-control study.2016
Author(s)
Kawasaki A, Hasebe N, Hidaka M, Hirano F, Sada K, Kobayashi S, Yamada H, Furukawa H, Yamagata K, Sumida T, Miyasaka N, Tohma S, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N.
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Journal Title
PLoS ONE.
Volume: 11
Issue: 5
Pages: e0154393-e0154393
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] HLAクラスIIと強皮症2017
Author(s)
古川宏,岡笑美,川崎綾,島田浩太,杉井章二,松下貴史,橋本篤,小宮明子,福井尚志,小林幸司,長田侑,井畑淳,近藤裕也,永井立夫,瀬戸口京吾,岡本明子,岡本享,千葉実行,末松栄一,河野肇,片山雅夫,廣畑俊成,住田孝之,右田清志,長谷川稔,藤本学,佐藤伸一,長岡章平,竹原和彦,當間重人,土屋尚之
Organizer
第20回強皮症研究会議
Place of Presentation
アステラス製薬本社(東京都中央区)
Year and Date
2017-01-14
Related Report
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[Presentation] 食餌によるメトトレキサート毒性の増強2017
Author(s)
樋口貴士,吉村美郁,岡笑美,川崎綾,蕨栄治,水野聖哉,小野栄夫,高橋智,當間重人,土屋尚之,古川宏
Organizer
第38回日本臨床薬理学会学術総会
Related Report
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[Presentation] 食餌によるメトトレキサート毒性の増強2017
Author(s)
樋口貴士,吉村美郁,岡笑美,川崎綾,蕨栄治,水野聖哉,小野栄夫,高橋智,當間重人,土屋尚之,古川宏
Organizer
第28回日本リウマチ学会関東支部学術集会
Related Report
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[Presentation] 日本人全身性エリテマトーデスとHLA-G多型の関連2016
Author(s)
川崎綾,八谷有紀,古川宏,近藤裕也,伊藤聡,松本功,草生真規雄,天野浩文,須田昭子,長岡章平,瀬戸口京吾,永井立夫,廣畑俊成,島田浩太,杉井章二,岡本享,千葉実行,末松栄一,大野滋,片山雅夫,河野肇,髙崎芳成,橋本博史,住田孝之,當間重人,土屋尚之
Organizer
第60回日本リウマチ学会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-04-21
Related Report
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