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Mechanisms to control the number and size of the nucleolus

Research Project

Project/Area Number 16K15166
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionChiba University

Principal Investigator

Saito Tetsuichiro  千葉大学, 大学院医学研究院, 教授 (00202078)

Co-Investigator(Renkei-kenkyūsha) MUROYAMA Yuko  千葉大学, 大学院医学研究院, 特任講師 (20422248)
BABA Atsushi  千葉大学, 大学院医学研究院, 特任講師 (70405215)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords遺伝子 / ゲノム / 細胞・組織 / 発現制御 / 発生・分化 / 電気穿孔法 / 神経幹細胞
Outline of Final Research Achievements

The nucleolus, in which rRNA is transcribed and processed, and ribosomal subunits are formed in eukaryotic cells, disassembles and reassembles every cell division. The number and size of the nucleolus are typical of cell types, but the mechanism to control them is largely unknown. We found that Nepro, which is necessary for the maintenance of early neural stem cells in the neocortex, is also crucial for the size and number of the nucleolus in preimplantation embryos. We have also found that Nepro is localized in a specific part of the nucleolus, and its QVEQC, hydrophobic and DDIDDIF domains, and nuclear localization signal are necessary for the function of Nepro.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] In vitro formation of the Merkel cell-neurite complex in embryonic mouse whiskers using organotypic co-cultures2018

    • Author(s)
      Ishida Kentaro、Saito Tetsuichiro、Mitsui Toshiyuki
    • Journal Title

      Development Growth Differentiation

      Volume: 印刷中 Issue: 5 Pages: 291-299

    • DOI

      10.1111/dgd.12535

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organizing activity of Fgf8 on the anterior telencephalon.2017

    • Author(s)
      Sato T, Kikkawa T, Saito T, Itoi K, Osumi N
    • Journal Title

      Dev Growth Differ

      Volume: 59 Issue: 9 Pages: 701-712

    • DOI

      10.1111/dgd.12411

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling.2016

    • Author(s)
      Yuko Muroyama, Atsushi Baba, Motoo Kitagawa, Tetsuichiro Saito
    • Journal Title

      PLOS Genetics

      Volume: 12(12) Issue: 12 Pages: e1006514-e1006514

    • DOI

      10.1371/journal.pgen.1006514

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distorted coarse axon targeting and reduced dendrite connectivity underlie dysosmia after olfactory axon2016

    • Author(s)
      Murai A, Iwata R, Fujimoto S, Aihara S, Tsuboi A, Muroyama Y, Saito T, Nishizaki K and Imai T
    • Journal Title

      eNeuro

      Volume: 3 Issue: 5 Pages: 1-13

    • DOI

      10.1523/eneuro.0242-16.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Mouse homing behavior and dendritic complexity of mitral cells are controlled by Notch signaling2017

    • Author(s)
      Atsushi Baba、Yuko Muroyama、Motoo Kitagawa、Tetsuichiro Saito
    • Organizer
      Neuroscience2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Formation of discrete olfactory circuits by spontaneous activity2017

    • Author(s)
      Takeshi Imai、Satoshi Fujimoto、Marcus Leiwe、Yuko Muroyama、Tetsuichiro Saito
    • Organizer
      Neuroscience2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of Fgf8 for development of the frontal cortex subdivisions2017

    • Author(s)
      Tatsuya Sato、Takako Kikkawa、Tetsuichiro Saito、Seiichi Itoi、Noriko Osumi
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Notch signaling controls dendritic complexity of mitral cells2016

    • Author(s)
      Yuko Muroyama, Motoo Kitagawa, Tetsuichiro Saito
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Intrinsic Spontaneous Network Activity in the Neonatal Mouse Olfactory Bulb is Required for Dendrite Pruning of Mitral Cells2016

    • Author(s)
      MN. Leiwe, S. Fujimoto, Y. Muroyama, R. Kobayakawa, K. Kobayakawa, T. Saito, T. Imai
    • Organizer
      Annual Meeting of Society for Neuroscience 2016
    • Place of Presentation
      Convention Center (San Diego, U.S.A)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Developmentally-regulated spontaneous network activity governs dendrite pruning of mitral cells to establish discrete connectivity2016

    • Author(s)
      Satoshi Fujimoto, Marcus N. Leiwe, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai
    • Organizer
      Cold Spring Harbor Laboratory 2016 Meeting "Axon Guidance, Synapse Formation and Regeneration"
    • Place of Presentation
      Cold Spring Harbor Laboratory (Cold Spring Harbor, U.S.A.)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 千葉大学 医学研究院 発生再生医学研究領域

    • URL

      http://www.m.chiba-u.ac.jp/class/dev/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 千葉大学 大学院医学研究院 発生再生医学研究領域

    • URL

      http://www.m.chiba-u.ac.jp/class/dev/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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