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Mechanism underlying chronic pain seen in the animal model for the chronic fatigue syndrome

Research Project

Project/Area Number 16K15170
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionNagoya University

Principal Investigator

Kiyama Hiroshi  名古屋大学, 医学系研究科, 教授 (00192021)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords疲労 / 慢性ストレス / 慢性炎症 / 運動神経 / 解剖学 / 神経科学 / 疲労科学 / ストレス
Outline of Final Research Achievements

Our previous study using animal model for chronic fatigue syndrome (CFS) suggested that the pain observed in patients with CFS and fibromyalgia syndrome (FMS) involves microglial activation, and therefore in the present study, we investigated the mechanism underlying the pain. Our results suggested that the stress loading elicits continuous and specific hyper-activation of proprioceptors in the dorsal root ganglia, and the hyper-activated signal triggers microglial activation in the specific regions of spinal cord. These activated regions locate along the spinal reflex arc, and the activated microglia along the arc thereby inducing prolonged and abnormal levels of pain. The results indicate that proprioceptor-induced microglial activation may be crucial in the initiation and maintenance of abnormal pain in patients with CFS.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Int'l Joint Research] Chongqing Medical University(China)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia2017

    • Author(s)
      Wei Li、Tokizane Kyohei、Konishi Hiroyuki、Yu Hua-Rong、Kiyama Hiroshi
    • Journal Title

      Journal of Neuroinflammation

      Volume: 14 Issue: 1 Pages: 198-198

    • DOI

      10.1186/s12974-017-0970-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain2016

    • Author(s)
      Kobayashi M, Konishi H, Sayo A, Takai T, Kiyama H
    • Journal Title

      J Neurosci

      Volume: 36(43) Issue: 43 Pages: 11138-11150

    • DOI

      10.1523/jneurosci.1238-16.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 持続的ストレス負荷ラットの肝細胞変性メカニズムの検討2017

    • Author(s)
      小川登紀子、田中雅彰、木山博資、渡邊恭良
    • Organizer
      第122回日本解剖学会総会
    • Place of Presentation
      長崎大学(長崎県・長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Microglial debris are phagocytosed by astrocytes upon microglial ablation in mice2017

    • Author(s)
      Konishi H, Sato K, Kiyama H
    • Organizer
      グリア研究会 (一般演題口頭発表)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microglia as a determinant of injured neuron fate2017

    • Author(s)
      Kiyama H
    • Organizer
      2017 FAN symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新たな技術による末梢神経再生メカニズム研究の新展開2017

    • Author(s)
      木山博資
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The morphological and functional biology of nerve regeneration2017

    • Author(s)
      Kiyama H
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティー浜松(静岡・浜松)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] TREM2/DAP12を介するミクログリア活性化は神経障害性疼痛を増悪させる2016

    • Author(s)
      小西博之 小林正明 高井俊行 木山博資
    • Organizer
      第59回日本神経化学会大会
    • Place of Presentation
      福岡国際会議場(福岡・博多)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 中枢での痛み記憶素子としてのミクログリア2016

    • Author(s)
      木山博資、安井正佐也、校條由紀
    • Organizer
      第12回日本疲労学会総会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県・横浜市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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