Reconstitution of experimental system for subcellular analysis of axon and optimal mathematical model
| Project/Area Number |
16K15177
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 軸索 / 海馬 / サブセルラー記録 / 生理学 / 脳・神経 / 神経科学 / シグナル伝達 / 薬理学 |
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| Outline of Final Research Achievements |
In this study, we aimed to establish comprehensive subcellular analysis of hippocampal mossy fiber axons, which allow direct recording of action potentials from exceptionally large axon terminals, to examine the properties and distribution of ionic channels on the axonal membrane. It has been shown that some sodium channels contributed to generation of afterdepolarization lasting for tens of milliseconds. It was also attempted to revise the mathematical model to reconstitute axonal action potentials as well as the following afterdepolarization. We successfully revised the mossy fiber models to display robust afterdepolarization similar to those observed experimentally.
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Report
(3 results)
Research Products
(18 results)
