| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we aimed to establish comprehensive subcellular analysis of hippocampal mossy fiber axons, which allow direct recording of action potentials from exceptionally large axon terminals, to examine the properties and distribution of ionic channels on the axonal membrane. It has been shown that some sodium channels contributed to generation of afterdepolarization lasting for tens of milliseconds. It was also attempted to revise the mathematical model to reconstitute axonal action potentials as well as the following afterdepolarization. We successfully revised the mossy fiber models to display robust afterdepolarization similar to those observed experimentally.
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