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Controlling of the ion channel clustering and collective function by photoresponsive DNA

Research Project

Project/Area Number 16K15178
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKanazawa University (2017)
University of Fukui (2016)

Principal Investigator

Sumino Ayumi  金沢大学, 新学術創成研究機構, 助教 (80717140)

Co-Investigator(Kenkyū-buntansha) 神谷 由紀子  名古屋大学, 工学研究科, 准教授 (00527947)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsイオンチャネル / 光応答性DNA / 光制御 / DNA / 架橋体 / カリウムチャネル / 光刺激
Outline of Final Research Achievements

Recently, we have focused on the relationship between clustering and dispersion of ion channels and its functions. In this study, we have controlled the distance between channels by using photoresponsive DNA as a crosslinking agent for ion channels. By designing DNA with an appropriate sequence, we succeeded in controlling the distance between channels at room temperature.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Oriented Reconstitution of the Full-Length KcsA Potassium Channel in a Lipid Bilayer for AFM Imaging2017

    • Author(s)
      Ayumi Sumino, Takayuki Uchihashi and Shigetoshi Oiki
    • Journal Title

      J. Phys. Chem. Lett.

      Volume: 8 Issue: 4 Pages: 785-793

    • DOI

      10.1021/acs.jpclett.6b03058

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 32017

    • Author(s)
      Iwamoto M, Sumino A, Shimada E, Kinoshita M, Matsumori N, Oiki S
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 10782-10782

    • DOI

      10.1038/s41598-017-11135-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] High-speed AFM revealed single-molecule blocking dynamics of a scorpion toxin on the KcsA potassium channel2017

    • Author(s)
      A. Sumino, T. Uchihashi, T. Sumikama, S. Oiki
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティ(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] ORIENTED RECONSTITUTION OF THE FULL-LENGTH KCSA POTASSIUM CHANNEL IN A LIPID BILAYER FOR AFM IMAGING OF SUPRAMOLECULAR ASSEMBLY2017

    • Author(s)
      Ayumi Sumino, Takayuki Uchihashi, Shigetoshi Oiki
    • Organizer
      Biophysical Society 61st Annual Meeting
    • Place of Presentation
      America, New Orleans
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膜タンパク質を配向制御してマイカ基板上の固定化平面膜に再構成する簡便な手法2017

    • Author(s)
      角野 歩、内橋 貴之、老木 成稔
    • Organizer
      平成28年度 日本生物物理学会 中部支部講演会
    • Place of Presentation
      名古屋(愛知県名古屋市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Single-molecule blocking dynamics of a scorpion toxin on the KcsA potassium channel revealed by HS-AFM2016

    • Author(s)
      Ayumi Sumino, Takashi Sumikama, Takayuki Uchihashi, Shigetoshi Oiki
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] HS-AFM revealed blocking dynamics of a scorpion toxin on the KcsA potassium channel2016

    • Author(s)
      Ayumi Sumino, Takayuki Uchihashi, Toshio Ando, Shigetoshi Oiki
    • Organizer
      4th Kanazawa Bio-AFM Workshop
    • Place of Presentation
      KKRホテル金沢(石川県金沢市)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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