Understanding of the purinergic signaling using spider toxins and insecticides
| Project/Area Number |
16K15180
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kagawa University (2018)
Osaka University (2016-2017) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ion channel / イオンチャネル / ATP受容体 / 生理学 / 薬理学 |
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| Outline of Final Research Achievements |
Purinergic ATP receptor channels (P2X) are responsible for maintaining various physiological functions such as pain sensation and transmission, dilation of blood vessels and inflammatory reaction. These physiological functions are exhibited by membrane excitation and Ca2+ dependent cellular reactions through P2X. In this study we explored the molecular basis of ion selectivity and its physiological roles using blockers and activators of P2X.
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| Academic Significance and Societal Importance of the Research Achievements |
ATP受容体のP2Xは、痛みの受容と伝達、血管の拡張、炎症反応など様々な生理機能に関係している。これら生理機能はP2Xから流入する陽イオンによる膜の興奮やCa2+による細胞内応答により発揮される。本研究により、P2Xのイオンの透過性の分子基盤とその生理機能が明らかになったことにより、将来的には、新しいタイプの鎮痛薬や抗高血圧薬への開発が期待される。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Conductance of P2X4 receptor is determined by conformational equilibrium in the transmembrane region2016
Author(s)
Minato Y, Suzuki S , Hara T, Kofuku Y, Kasuya G, Fujiwara Y, Igarashi S, Suzuki E, Nureki O, Hattori M, Ueda T, Shimada I
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Journal Title
Proc. Natl. Acad. Sci.
Volume: 発行中
Issue: 17
Pages: 4741-4746
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Crystal structures of the TRIC trimeric intracellular cation channel orthologues.2016
Author(s)
Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.
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Journal Title
Cell Res.
Volume: 26
Issue: 12
Pages: 1288-1301
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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