Research Project
Grant-in-Aid for Challenging Exploratory Research
Recently, adhesion-type G protein-coupled receptors (ADGRs) have been intensively studied as molecules which regulate synapse integrity and learning & memory in the CNS. ADGR has a unique structure which contains an extracellular N-terminal domain with various types of functional domains, a seven-transmembrane region and an intracellular domain interacting with several signal molecules including G proteins. Despite its unique structure, the mechanisms by which ADGR behaves at synapses have remained unclear. In this study, we demonstrated that a brain-specific angiogenesis inhibitor 3 (BAI3), an ADGR member abundantly expressed at the synapses between climbing fiber (CF) and Purkinje cell in the cerebellum, plays crucial roles in synapse morphology, synaptic plasticity and cerebellar motor learning.
All 2018 2017 2016 Other
All Int'l Joint Research Journal Article Presentation Book Remarks
実験医学 (羊土社)
Volume: 印刷中
BRAIN and NERVE-神経研究の進歩 (医学書院社)
脳の分子論 (東京化学同人社)
Nat. Commun.
Volume: 印刷中 Pages: 14850-14850
Clinical Neuroscience (中外医学社)
Volume: 5 Pages: 523-527
Science
Volume: 353 Pages: 295-299
Volume: 34 Pages: 3181-3184
Neuron
Volume: 90 Pages: 752-67
Annual Review神経2016 (中外医学社)
Volume: - Pages: 35-43