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The role of the cell cytoskeleton in the insulin secretion control

Research Project

Project/Area Number 16K15185
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionNational Institute for Basic Biology

Principal Investigator

Noda Masaharu  基礎生物学研究所, 統合神経生物学研究部門, 教授 (60172798)

Research Collaborator SHINTANI Takafumi  基礎生物学研究所, 統合神経生物学研究部門, 准教授 (10312208)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsインスリン分泌 / APC2 / 細胞骨格 / 膵β細胞 / 膵島
Outline of Final Research Achievements

We found that Apc2-deficeint mice exhibited a higher glucose-induced insulin secretion compared with wild-type mice. Experiments using isolated islets from Apc2-deificient mice and mouse islet cell line MIN6 revealed that APC2 was not implicated in the regulation of insulin secretion at the β-cell level. We found that APC2 was highly expressed in the nerve fibers projecting to pancreatic islets, which suggested that APC2 may play a role in the regulation of insulin secretion through the autonomic nervous system.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] APC2の欠損は知的障害の原因となる2016

    • Author(s)
      新谷隆史、竹内靖、藤川顕寛、久保山和哉、野田昌晴
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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