Central pathways mediating autonomic cardiovascular adjustments to fear
| Project/Area Number |
16K15190
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Tottori University |
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Principal Investigator |
Koba Satoshi 鳥取大学, 医学部, 准教授 (40565743)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 恐怖 / 徐脈 / 自律神経 / 恐怖心 / 副交感神経 / 交感神経 / 光遺伝学 / テレメトリー / すくみ / 中脳中心灰白質 / 視床下部 / 扁桃体 / 免疫染色 |
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| Outline of Final Research Achievements |
This project aimed to identify central circuitries underlying fear bradycardia. The neural tracing experiments combined with immunofluorescence found several central cardiovascular multisynaptic pathways throughout the rat whole brain. In vivo observations of cardiovascular parameters during fear in rats combined with optogenetics or DREADDs were further conducted to determine functional roles a cardiovascular pathway identified by neural tracing experiments plays in fear bradycardia. Selective inhibition of neuronal excitation by the cardiovascular pathway did not affect fear bradycardia in conscious rats.
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Report
(3 results)
Research Products
(18 results)
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[Presentation] 運動トレーニングと循環中枢回路2016
Author(s)
木場智史、花井映里、熊田奈桜
Organizer
SICEライフエンジニアリング部門シンポジウム
Place of Presentation
大阪国際交流センター(大阪府大阪市)
Year and Date
2016-11-03
Related Report
Invited
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