| Project/Area Number |
16K15191
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
UEBANSO Takashi 徳島大学, 大学院医歯薬学研究部(医学系), 特任助教 (10581829)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 栄養学 / 代謝 / 腸内細菌叢 / 栄養 / 腸内環境 / プロバイオティクス |
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| Outline of Final Research Achievements |
In this study, we focused on vitamins among the nutrients whose deficiency is pointed out in Japanese national health nutrition survey etc., and comprehensively analyzed metabolites concentration on B-vitamins (B2, B6, B9, B12) deficient diet fed mice. We found a metabolite whose concentration rises when vitamin deficiency occurs. Since this metabolite is not produced in a state where the intestinal bacterial flora is destroyed, it is considered that at least a part of it is synthesized by intestinal bacteria. In addition, abnormal responsiveness to nutrient deficiency was observed in mice that broke the intestinal bacterial flora. Based on these findings, analyzing metabolic substances of meal components by intestinal bacterial flora likely to not only estimate the dietary ingredients intake, but it is lead to the development of a method of evaluating the host's intestinal environment.
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