| Project/Area Number |
16K15194
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
ISHII Isao 昭和薬科大学, 薬学部, 教授 (90292953)
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| Research Collaborator |
KAMATA Shotaro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 摂食拒絶 / 必須アミノ酸 / 非必須アミノ酸 / 拒食症 / 摂食 / アミノ酸 / 遺伝子改変マウス / 行動学 / 栄養学 / 生理学 / 神経科学 |
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| Outline of Final Research Achievements |
We investigated the physiological correlation between food rejection behavior and serum amino acid (AA) profiles upon single AA-deficient diets in mice. When fed an essential AA-deprived diet, we observed decreased serum levels of the corresponding AA followed by food rejection (although the time of onset differs among the diets). Meanwhile, when fed a non-essential AA-deprived diet, both food rejection and its preceding serum AA level change were not observed. Furthermore, when fed a non-essential cyst(e)ine-deprived diet, normal (wild-type) mice did not show food rejection as well as serum Cys level decrease; however, genetically-engineered mice deficient in Cys biosynthesis (cystathionine gamma-lyase [CSE]-knockout mice) did show those. There results suggest that food rejection upon AA deprivation from diet could occur when serum levels of any proteinogenic AA are declined.
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