Mechanism of food rejection upon amino acid-unbalanced diet
| Project/Area Number |
16K15194
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
ISHII Isao 昭和薬科大学, 薬学部, 教授 (90292953)
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| Research Collaborator |
KAMATA Shotaro
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 摂食拒絶 / 必須アミノ酸 / 非必須アミノ酸 / 拒食症 / 摂食 / アミノ酸 / 遺伝子改変マウス / 行動学 / 栄養学 / 生理学 / 神経科学 |
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| Outline of Final Research Achievements |
We investigated the physiological correlation between food rejection behavior and serum amino acid (AA) profiles upon single AA-deficient diets in mice. When fed an essential AA-deprived diet, we observed decreased serum levels of the corresponding AA followed by food rejection (although the time of onset differs among the diets). Meanwhile, when fed a non-essential AA-deprived diet, both food rejection and its preceding serum AA level change were not observed. Furthermore, when fed a non-essential cyst(e)ine-deprived diet, normal (wild-type) mice did not show food rejection as well as serum Cys level decrease; however, genetically-engineered mice deficient in Cys biosynthesis (cystathionine gamma-lyase [CSE]-knockout mice) did show those. There results suggest that food rejection upon AA deprivation from diet could occur when serum levels of any proteinogenic AA are declined.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion2017
Author(s)
Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
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Journal Title
Nucleic Acids Research
Volume: 45
Pages: 435-445
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.2016
Author(s)
Wedmann R, Onderka C, Wei S, Szijarto IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR.
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Journal Title
Chem Sci
Volume: 7
Pages: 3414-3426
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice.2016
Author(s)
Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.
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Journal Title
Endocrinology
Volume: 印刷中
Pages: 1839-1851
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury.2016
Author(s)
Marko L, Szijarto IA, Filipovic MR, Kassmann M, Balogh A, Park JK, Przybyl L, N'Diaye G, Kramer S, Anders J, Ishii I, Muller DN, Gollasch M.
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Journal Title
Sci Rep
Volume: 6
Pages: 27517-27517
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immobilization of the gas signaling molecule H2S by radioisotopes: detection, quantification, and in vivo imaging.2016
Author(s)
Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J.
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Journal Title
Angew Chem Int Ed Engl
Volume: 55
Pages: 9365-9370
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Dietary deprivation of each proteinogenic amino acid induces altered systemic responses in mice.2016
Author(s)
Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagia Y, Kubota M, Ohkubo R, Karube K, Kasahara T, Ishii I.
Organizer
The 9th International Conference on the Biology, Chemistry, and Therapeutic applications of NO.
Place of Presentation
仙台国際センタ－（宮城県 仙台市）
Related Report
Int'l Joint Research
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