• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism of food rejection upon amino acid-unbalanced diet

Research Project

Project/Area Number 16K15194
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionShowa Pharmaceutical University

Principal Investigator

ISHII Isao  昭和薬科大学, 薬学部, 教授 (90292953)

Research Collaborator KAMATA Shotaro  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords摂食拒絶 / 必須アミノ酸 / 非必須アミノ酸 / 拒食症 / 摂食 / アミノ酸 / 遺伝子改変マウス / 行動学 / 栄養学 / 生理学 / 神経科学
Outline of Final Research Achievements

We investigated the physiological correlation between food rejection behavior and serum amino acid (AA) profiles upon single AA-deficient diets in mice. When fed an essential AA-deprived diet, we observed decreased serum levels of the corresponding AA followed by food rejection (although the time of onset differs among the diets). Meanwhile, when fed a non-essential AA-deprived diet, both food rejection and its preceding serum AA level change were not observed. Furthermore, when fed a non-essential cyst(e)ine-deprived diet, normal (wild-type) mice did not show food rejection as well as serum Cys level decrease; however, genetically-engineered mice deficient in Cys biosynthesis (cystathionine gamma-lyase [CSE]-knockout mice) did show those. There results suggest that food rejection upon AA deprivation from diet could occur when serum levels of any proteinogenic AA are declined.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2018 2017 2016 Other

All Int'l Joint Research (7 results) Journal Article (12 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 12 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results)

  • [Int'l Joint Research] kyungpook National University/Keimyung University(韓国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Friedrich-Alexander University/Charity Campus Virchow/Erlangen University(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Exeter(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Universite Paris Descartes(フランス)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Washington State University/University of Michigan, Ann Arbor(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Kyungpook National University/Korea Institute of Radiol and Med Sci(韓国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2016 Research-status Report
  • [Journal Article] Hydrogen sulfide inhibits the NLRP3 inflammasome and reduces cytokine production both in vitro and in a mouse model of inflammation2018

    • Author(s)
      Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, Martinon F, Busso N
    • Journal Title

      J Biol Chem

      Volume: 293 Issue: 7 Pages: 2546-2557

    • DOI

      10.1074/jbc.m117.806869

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural and functional insights into S-thiolation of human serum albumins.2018

    • Author(s)
      Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Gimenez-Bastida JA, Schneider C, Uchida K
    • Journal Title

      Sci Rep.

      Volume: 8(1) Issue: 1 Pages: 932-932

    • DOI

      10.1038/s41598-018-19610-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017

    • Author(s)
      Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
    • Journal Title

      Chem Res Toxicol

      Volume: 30 Issue: 12 Pages: 2209-2217

    • DOI

      10.1021/acs.chemrestox.7b00278

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis2017

    • Author(s)
      Han Sang Jun、Noh Mi Ra、Jung Jung-Min、Ishii Isao、Yoo Jeongsoo、Kim Jee In、Park Kwon Moo
    • Journal Title

      Free Radic Biol Med

      Volume: 112 Pages: 423-432

    • DOI

      10.1016/j.freeradbiomed.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid 2D DIGE Proteomic Analysis of Mouse Liver2017

    • Author(s)
      Kamata Shotaro、Ishii Isao
    • Journal Title

      Methods Mol Biol

      Volume: 1664 Pages: 153-166

    • DOI

      10.1007/978-1-4939-7268-5_13

    • ISBN
      9781493972678, 9781493972685
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.2017

    • Author(s)
      Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    • Journal Title

      Nucleic Acids Res.

      Volume: 45 Issue: 1 Pages: 435-445

    • DOI

      10.1093/nar/gkw745

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.2016

    • Author(s)
      Wedmann R, Onderka C, Wei S, Szijarto IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR.
    • Journal Title

      Chemical Science

      Volume: 7 Issue: 5 Pages: 3414-3426

    • DOI

      10.1039/c5sc04818d

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice2016

    • Author(s)
      Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.
    • Journal Title

      Endocrinology

      Volume: 印刷中 Issue: 5 Pages: 1839-1851

    • DOI

      10.1210/en.2015-1768

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury.2016

    • Author(s)
      Marko L, Szijarto IA, Filipovic MR, Kassmann M, Balogh A, Park JK, Przybyl L, N'Diaye G, Kramer S, Anders J, Ishii I, Muller DN, Gollasch M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27517-27517

    • DOI

      10.1038/srep27517

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immobilization of the gas signaling molecule H2S by radioisotopes: detection, quantification, and in vivo imaging.2016

    • Author(s)
      Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J.
    • Journal Title

      Angewandte Chemie (International ed. in English)

      Volume: 55 Issue: 32 Pages: 9365-9370

    • DOI

      10.1002/anie.201603813

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis.2016

    • Author(s)
      Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 8 Pages: e0160521-e0160521

    • DOI

      10.1371/journal.pone.0160521

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 二系統の高ホモシステイン血症マウスにおける脳脊髄液アミノ酸組成異常2018

    • Author(s)
      横山 輝, 赤星 軌征,石井 功
    • Organizer
      日本薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cystathionine gamma-lyase欠損母マウスにおける授乳行動異常2018

    • Author(s)
      赤星 軌征,半田 博紀,横山 輝,石井 功
    • Organizer
      日本薬学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cystathionine gamma-lyase欠損マウスにおける妊娠高血圧症候群と育児放棄2017

    • Author(s)
      赤星 軌征,半田 博紀,石井 功
    • Organizer
      フォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cystathionine gamma-lyase欠損マウスにおける乳清アミノ酸成分の異常2017

    • Author(s)
      半田 博紀,横山 輝, 赤星 軌征,石井 功
    • Organizer
      フォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel targets of homocysteine, a risk factor for cardiovascular disease2017

    • Author(s)
      Isao Ishii
    • Organizer
      韓国薬学会秋季国際学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新電子物質からの生体防御におけるトランススルフレーション酵素(CBS/CTH)の役割2016

    • Author(s)
      石井 功
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学(東京都 品川区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Possible roles of H2S/RSS and homocysteine in the redox signaling via electrophiles.2016

    • Author(s)
      Ishii I
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic applications of NO.
    • Place of Presentation
      仙台国際センタ-(宮城県 仙台市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dietary deprivation of each proteinogenic amino acid induces altered systemic responses in mice.2016

    • Author(s)
      Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagia Y, Kubota M, Ohkubo R, Karube K, Kasahara T, Ishii I.
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic applications of NO.
    • Place of Presentation
      仙台国際センタ-(宮城県 仙台市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dietary deprivation of each proteinogenic amino acid induces differential systemic responsess in mice.2016

    • Author(s)
      Kamata S, Yamamoto J, Karube K, Ohkubo R, Kasahara T, Ishii I.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 第6版 衛生薬学 ー健康と環境ー2018

    • Author(s)
      石井 功
    • Total Pages
      538
    • Publisher
      丸善出版株式会社
    • ISBN
      9784621301784
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi