| Project/Area Number |
16K15198
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 公雄 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 循環器・高血圧 / 大動脈瘤 / 医歯薬学 / 内科系臨床医学 / 循環器内科学 / 分子血管学 / 臨床応用研究 / 基礎医学 / 薬理学一般 / 心血管・血液 |
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| Outline of Final Research Achievements |
We conducted basic and clinical studies on the SmgGDS-mediated protective function of cardiovascular system. In particular, in order to investigate whether SmgGDS secreted extracellularly by statin stimulation has protective effects on vascular endothelium and cardiovascular system, we developed genetically-deficient mice and overexpressing mice in our department. Additionally, we performed in vitro studies on the role of intracellular SmgGDS which promoted Rac1 degradation while extracellular SmgGDS had an important role in suppressing fibroblast proliferation and MMP activities. Finally, in vivo study demonstrated that SmgGDS inhibits the development of thoracic aortic aneurysms and resulting aortic rupture.
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