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Functional analysis of novel cardiovascular protective factor

Research Project

Project/Area Number 16K15198
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionTohoku University

Principal Investigator

Shimokawa Hiroaki  東北大学, 医学系研究科, 教授 (00235681)

Co-Investigator(Kenkyū-buntansha) 佐藤 公雄  東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords循環器・高血圧 / 大動脈瘤 / 医歯薬学 / 内科系臨床医学 / 循環器内科学 / 分子血管学 / 臨床応用研究 / 基礎医学 / 薬理学一般 / 心血管・血液
Outline of Final Research Achievements

We conducted basic and clinical studies on the SmgGDS-mediated protective function of cardiovascular system. In particular, in order to investigate whether SmgGDS secreted extracellularly by statin stimulation has protective effects on vascular endothelium and cardiovascular system, we developed genetically-deficient mice and overexpressing mice in our department. Additionally, we performed in vitro studies on the role of intracellular SmgGDS which promoted Rac1 degradation while extracellular SmgGDS had an important role in suppressing fibroblast proliferation and MMP activities. Finally, in vivo study demonstrated that SmgGDS inhibits the development of thoracic aortic aneurysms and resulting aortic rupture.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 Other

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 5 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 5 results)

  • [Journal Article] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-2018

    • Author(s)
      Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Shimokawa H.
    • Journal Title

      Circulation

      Volume: ―

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension2018

    • Author(s)
      Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
    • Journal Title

      Heart Vessels.

      Volume: 33 Issue: 8 Pages: 939

    • DOI

      10.1007/s00380-018-1140-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shrinking basic cardiovascular research in Japan: A tip of the iceberg.2017

    • Author(s)
      Shimokawa H, Kikuchi N, Satoh K.
    • Journal Title

      Circ Res.

      Volume: 121 Issue: 4 Pages: 331-334

    • DOI

      10.1161/circresaha.117.310845

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] European Society of Cardiology (ESC) Annual Congress Report From Barcelona 20172017

    • Author(s)
      Satoh K, Takahashi J, Matsumoto Y, Tatebe S, Aoki T, Kikuchi Y, Hao K, Ohyama K, Nogi M, Suda A, Kasahara S, Sato K, Ichijo S, Shimokawa H.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 12 Pages: 1758-1763

    • DOI

      10.1253/circj.CJ-17-1103

    • NAID

      130006219237

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thrombo-embolic pulmonary hypertension: Long-term effects and procedure-related complications2017

    • Author(s)
      Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Miyata S, Nochioka K, Satoh K, Shimokawa H.
    • Journal Title

      Eur Heart J.

      Volume: 38 Issue: 42 Pages: 3152

    • DOI

      10.1093/eurheartj/ehx530

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Efficacy of a Genetic Analysis of the <i>BMPR2</i> Gene in a Patient with Severe Pulmonary Arterial Hypertension and an Atrial Septal Defect Treated with Bilateral Lung Transplantation2017

    • Author(s)
      Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Satoh K, Fukuda K, Adachi O, Saito R, Nakanishi N, Morisaki H, Oyama K, Saiki Y, Okada Y, Shimokawa H.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 23 Pages: 3193-3197

    • DOI

      10.2169/internalmedicine.8686-16

    • NAID

      130006235510

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis: Novel mechanism of the pleiotropic effects of statins2016

    • Author(s)
      Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
    • Journal Title

      Hypertension

      Volume: 67 Issue: 5 Pages: 878

    • DOI

      10.1161/hypertensionaha.115.07089

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells2016

    • Author(s)
      Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
    • Journal Title

      Cardiovasc Res.

      Volume: 109 Issue: 1 Pages: 151

    • DOI

      10.1093/cvr/cvv253

    • URL

      https://pure.teikyo.jp/en/publications/a353137b-83d5-4f19-9359-43d0dbeb0fd4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] RhoA/Rho-kinase in the cardiovascular system.2016

    • Author(s)
      Shimokawa H, Sunamura S, Satoh K.
    • Journal Title

      Circ Res.

      Volume: 118 Issue: 2 Pages: 352-366

    • DOI

      10.1161/circresaha.115.306532

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Selenoprotein P promotes the development of pulmonary arterial hypertension-A Possible Novel Therapeutic Target-2018

    • Author(s)
      Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Abdul Hai Siddique M, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
    • Organizer
      World Symposium on Pulmonary Hypertension
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ADAMTS8 Promotes the Development of pulmonary arterial hypertension and right ventricular failure-A possible novel therapeutic target-2018

    • Author(s)
      Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Elias-Al-Mamun M, Abdul Hai Siddique M, Yaoita N, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
    • Organizer
      World Symposium on Pulmonary Hypertension
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of celastramycin as a novel therapeutic agent for pulmonary arterial hypertension -High-throughput screening of 5,562 compounds-2018

    • Author(s)
      Kurosawa R, Satoh K, Kikuchi N, Satoh T, Omura J, Nogi M, Sunamura S, Ohtsuki T, Yaoita N, Abdul Hai Siddique M, Elias-Al-Mamun M, Shimizu T, Shimokawa H.
    • Organizer
      World Symposium on Pulmonary Hypertension
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Different roles of myocardial ROCK1 and ROCK2 in response to chronic pressure-overload in mice.2018

    • Author(s)
      Sunamura S, Satoh K, Shimizu T, Suzuki K, Ikeda S, Kudo S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Shimokawa H.
    • Organizer
      World Symposium on Pulmonary Hypertension
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds-2018

    • Author(s)
      Abdul Hai Siddique M, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
    • Organizer
      World Symposium on Pulmonary Hypertension
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 特集/SGLT2心腎連関 解説 Cyclophilin A(2017年10月号)2017

    • Author(s)
      佐藤 公雄、下川 宏明.
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学循環器内科ホームページ

    • URL

      http://www.cardio.med.tohoku.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] セレノプロテインP活性阻害作用を有する成分を含有する、肺高血圧症の予防又は治療剤2017

    • Inventor(s)
      下川宏明、佐藤公雄、菊地順裕
    • Industrial Property Rights Holder
      下川宏明、佐藤公雄、菊地順裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生薬成分を含む肺高血圧症の予防又は治療剤2017

    • Inventor(s)
      下川宏明, 佐藤公雄, 黒澤亮
    • Industrial Property Rights Holder
      下川宏明, 佐藤公雄, 黒澤亮
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 不飽和複素5員環含有化合物を含有する肺高血圧症の予防又は治療剤2017

    • Inventor(s)
      下川宏明, 佐藤公雄, 黒澤亮
    • Industrial Property Rights Holder
      下川宏明, 佐藤公雄, 黒澤亮
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] PPARαアゴニストを含有する、肺高血圧症の予防又は治療剤2017

    • Inventor(s)
      下川宏明、佐藤公雄、佐藤大樹
    • Industrial Property Rights Holder
      下川宏明、佐藤公雄、佐藤大樹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] サイクロフィリンAによる心血管疾患の検査方法2016

    • Inventor(s)
      下川宏明、佐藤公雄
    • Industrial Property Rights Holder
      下川宏明、佐藤公雄
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 肺高血圧症の検査方法2016

    • Inventor(s)
      下川宏明、佐藤公雄、菊地順裕
    • Industrial Property Rights Holder
      下川宏明、佐藤公雄、菊地順裕
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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