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Development of a novel method for the identification of ncRNA-binding proteins

Research Project

Project/Area Number 16K15212
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Takekawa Mutsuhiro  東京大学, 医科学研究所, 教授 (30322332)

Research Collaborator KUBOTA YUJI  東京大学, 医科学研究所, 助教 (70614973)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords非コードRNA / 蛋白質 / 機能性RNA / 核酸 / 細胞 / 生体分子 / バイオテクノロジー / プロテオーム
Outline of Final Research Achievements

Non-coding (nc) RNAs are functional RNA molecules that are transcribed from genomic DNA. Recent studies have demonstrated that various ncRNAs (e.g., miRNAs and lncRNAs) play important roles in the regulation of diverse cellular functions such as cell proliferation, and apoptosis through interacting with specific RNAs or proteins. Furthermore, accumulating evidence showed that abnormal expression of ncRNAs is involved in the etiology of human diseases including cancers. However, the functions of individual ncRNAs remain largely unknown. In this study, we aimed to establish a novel method to identify proteins that selectively bind to a specific ncRNA. For this purpose, we performed several pilot studies using a representative lncRNA, whose binding partners have already been identified. By constructing various expression vectors and optimizing experimental conditions, we succeeded in establishing the novel method. This method will greatly advance our understanding of ncRNAs.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (78 results)

All 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (63 results) (of which Int'l Joint Research: 12 results,  Invited: 17 results) Remarks (2 results)

  • [Int'l Joint Research] University Clinic Munster(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] MD Anderson Cancer Center/NCI, NIH/Johns Hopkins University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute, NIH/Johns Hopkins University(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Jawaharlal Nehru University,(インド)

    • Related Report
      2016 Research-status Report
  • [Journal Article] A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.2018

    • Author(s)
      M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa, M. Shibasaki.
    • Journal Title

      J. Antibiot.

      Volume: 71 Issue: 1 Pages: 135-138

    • DOI

      10.1038/ja.2017.100

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins2017

    • Author(s)
      Kubota Yuji、Fujioka Ko、Takekawa Mutsuhiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0180714-e0180714

    • DOI

      10.1371/journal.pone.0180714

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas2017

    • Author(s)
      Ichimanda Michihiro、Hijiya Naoki、Tsukamoto Yoshiyuki、Uchida Tomohisa、Nakada Chisato、Akagi Tomonori、Etoh Tsuyoshi、Iha Hidekatsu、Inomata Masafumi、Takekawa Mutsuhiro、Moriyama Masatsugu
    • Journal Title

      Cancer Sci

      Volume: 109 Issue: 1 Pages: 250-258

    • DOI

      10.1111/cas.13444

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.2016

    • Author(s)
      Arimoto-Matsuzaki K, Saito H and Takekawa M.
    • Journal Title

      Nature Commun.

      Volume: 7 Issue: 1

    • DOI

      10.1038/ncomms10252

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma.2016

    • Author(s)
      Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.
    • Journal Title

      Cancer Res.

      Volume: 76 Issue: 9 Pages: 2612-2625

    • DOI

      10.1158/0008-5472.can-15-1846

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.2016

    • Author(s)
      Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.
    • Journal Title

      Proteomics

      Volume: 16 Issue: 13 Pages: 1825-1836

    • DOI

      10.1002/pmic.201500494

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection and functional analysis of SUMO-modified MEK.2016

    • Author(s)
      Kubota Y and Takekawa M.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1487 Pages: 99-111

    • DOI

      10.1007/978-1-4939-6424-6_7

    • ISBN
      9781493964222, 9781493964246
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MAPキナーゼ情報伝達経路の活性制御機構と疾患発症機構の解明2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60 Pages: 7-10

    • NAID

      130005249511

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Journal Title

      生物物理化学 電気泳動

      Volume: 60

    • Related Report
      2016 Research-status Report
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2018

    • Author(s)
      武川睦寛
    • Organizer
      第1回MMDS/IMSUT/CBM合同ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ERKシグナルによる癌抑制遺伝子のエピゲノム・サイレンシングと発がん2018

    • Author(s)
      武川睦寛
    • Organizer
      東京生化学研究会2017年度研究報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] フィードバック・リン酸化によるERKシグナル制御機構の数理シミュレーション解析2018

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      第1回MMDS、医科学研究所、新領域創成科学研究科合同ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2018

    • Author(s)
      森泉寿士, 中村貴紀, 武川睦寛
    • Organizer
      新学術領域 数理シグナル 第二回 公開シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Aberrant post-translational modifications of the MEK MAPKK in cancer.2017

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      OIST seminar
    • Place of Presentation
      OIST(沖縄)
    • Year and Date
      2017-02-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] MAPKシグナルおよびストレス顆粒形成による細胞機能の制御と疾患2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Aberrant regulation of MAPK signaling pathways in cancer.2017

    • Author(s)
      Takekawa M
    • Organizer
      The 48th international symposium of the Princess Takamatsu cancer research fund
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 数理科学を活用した生命・医科学研究2017

    • Author(s)
      武川睦寛
    • Organizer
      数学教育学会2017夏季研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 数理解析を活用した中心体複製制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A novel method for the detection of O-GlcNAc-modified proteins: WGA-based lectin affinity gel electrophoresis (WGA-SDS-PAGE)2017

    • Author(s)
      Yuji Kubota, Ko Fujioka and Mutsuhiro Takekawa
    • Organizer
      プロテイン・アイランド松山
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      CIMR(Cambridge Institute for Medical Research)-University of Tokyo Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive analysis of stress granule components2017

    • Author(s)
      Daichi Fujikawa, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      Dundee-Tokyo Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes under stress2017

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      EMBO Conference “Centrosomes and Spindle Pole Bodies”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      24th East Asia Joint Symposium on Biomedical Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of a novel ERK substrate, MCRIP12017

    • Author(s)
      Jane Weng, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      12th International Symposium of the institute Network
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2017

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」領域推進会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中心体複製開始を司るPLK4中心体局在機構の解明2017

    • Author(s)
      中村貴紀、西住(渡海)紀子、中澤嵩、鈴木貴、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a novel redox-sensor that mediates delayed activation of stress-responsive MAPKs by oxidative stress2017

    • Author(s)
      Moe Matsushita, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification and phosphorylation analysis of a novel MAPK substrate2017

    • Author(s)
      Sae Uchida, Yuji Kubota, Mutsuhiro Takekawa
    • Organizer
      IMSUT G2リトリート
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス顆粒の形成機構および生理機能の解明2017

    • Author(s)
      藤川大地、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌抑制遺伝子MKK4のフィードバック・リン酸化の機能解析2017

    • Author(s)
      森泉寿士、中村貴紀、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌および先天性Ras/MAPK 症候群におけるMEK 変異体の異常活性化機構の解明と特異的阻害剤の同定2017

    • Author(s)
      久保田裕二、武川睦寛
    • Organizer
      新学術領域研究 数理シグナル 第1回若手ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] エクソソーム中に蓄積するがん特異的miRNAの同定およびその早期診断マーカーとしての応用2017

    • Author(s)
      広瀬思帆、久保田裕二、武川睦寛
    • Organizer
      GLAFS研究進捗状況報告会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛋白質O-GlcNAc化によるMAPK経路の新たな制御メカニズムの解明2017

    • Author(s)
      藤岡興、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of novel ERK substrates by yeast three hybrid screening2017

    • Author(s)
      Seina Ohe, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2017

    • Author(s)
      Hisashi Moriizumi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of a novel protein that is induced by hyperactiveation of the ERK pathway2017

    • Author(s)
      Yusuke Takagi, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of a novel O-GlcNAc protein involved in the MAPK pathway2017

    • Author(s)
      Ko Fujioka, Yuji Kubota and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Negative regulation of the ERK pathway by caspase-mediated cleavage of MEK1 during apoptosis.2017

    • Author(s)
      Yuji Kubota, Tomoyuki Tsuchiya and Mutsuhiro Takekawa
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス応答キナーゼMTK1による新たなストレス感知・応答機構2017

    • Author(s)
      松下萌恵、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ERK経路の異常活性化により発現が亢進する新規遺伝子の同定と機能解析2017

    • Author(s)
      高木祐輔、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] シグナル伝達異常によって発現誘導される長鎖非コードRNAの同定と機能解析2017

    • Author(s)
      中野雄太、久保田裕二、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛋白質O-GlcNAc化を定量的かつ簡便に検出する新たな解析方法の開発2017

    • Author(s)
      久保田裕二、藤岡興、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス応答MAPK経路によって制御されるmiRNAの機能解析2017

    • Author(s)
      渡海紀子、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規ERK基質分子MCRIP1の生理機能解析2017

    • Author(s)
      Jane Weng、中村貴紀、武川睦寛
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス顆粒形成によるストレス応答の制御と疾患2016

    • Author(s)
      武川睦寛
    • Organizer
      Science Medical Frontier Forum
    • Place of Presentation
      TKPガーデンシティー品川(東京)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The molecular mechanisms that maintain the numerical integrity of centrosomes2016

    • Author(s)
      Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      American Society of Cell Biology (ASCB) annual meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] フィードバック・リン酸化によるERKシグナルと発癌の制御2016

    • Author(s)
      武川睦寛
    • Organizer
      第39回日本分子生物学会年会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ストレス応答MAPK経路依存的に発現調節されるmiRNAの同定2016

    • Author(s)
      西住(渡海)紀子、中村貴紀、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 酵母Three Hybrid法による新規ERK基質分子の同定と生理機能の解明2016

    • Author(s)
      大江星菜, 久保田裕二、武川睦寛
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] フォスタグ技術とプロテオミクス情報を活用した細胞内MEK1リン酸化ダイナミクスのプロファイリング2016

    • Author(s)
      木下英司、木下恵美子、久保田裕二、武川睦寛、小池透
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      Zizheng Li and Mutsuhiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of ERK-inducible long non-coding RNAs that are highly expressed in cancer2016

    • Author(s)
      Yuta Nakano and Mutshiro Takekawa
    • Organizer
      IMSUT G2 retreat
    • Place of Presentation
      検見川セミナーハウス(千葉)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Dysregulation of cell signaling pathways in cancer2016

    • Author(s)
      武川睦寛
    • Organizer
      第75回日本癌学会学術総会「がん研究入門コース1」
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] DUSP4の発現低下は膵上皮内癌から浸潤癌への進展に関与する2016

    • Author(s)
      Naoki Hijiya, Yoshiyuki Tsukamoto, Chisato Nakata, Tomoki Kai, Keiko Matsuura, Masafumi Inomata, Kuniaki Shirao, Hiromu Mori, Masao Seto, Masahiro Aoki, Mutsuhiro Takekawa, Masatsugu Moriyama
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] MCRIP1, a novel ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-to-mesenchymal transition2016

    • Author(s)
      Mutsuhiro Takekawa
    • Organizer
      15th Karolinska Institute Cancer Retreat
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of feedback-phosphorylation of MKK4 by MAPKs2016

    • Author(s)
      Moriizumi Hisashi, Takanori Nakamura and Mutsuhito Takekawa
    • Organizer
      IARU International Symposium on Aging, Longevity and Health
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膵上皮内癌が浸潤癌へ進展するメカニズムの解明2016

    • Author(s)
      守山正胤、泥谷直樹、塚本善之、柴田浩平、猪股雅史、森宣、白尾國昭、竹内一郎、瀬戸加大、青木正博、武川睦寛
    • Organizer
      第27回日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report
  • [Presentation] ストレス顆粒形成によるストレス誘導アポトーシスの制御と活性酸素によるその破綻2016

    • Author(s)
      武川睦寛
    • Organizer
      第67回日本電気泳動学会総会特別講演
    • Place of Presentation
      釧路市観光国際交流センター(釧路)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 数理解析に基づくMAPKシグナルと生命機能制御機構の解明2016

    • Author(s)
      武川睦寛
    • Organizer
      新学術領域「数理シグナル」計画班合同会議
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-08-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Comprehensive analysis of stress granule components2016

    • Author(s)
      李 子政、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Molecular mechanism by which PLK4 is recruited to centrosomes2016

    • Author(s)
      杉崎 麻友、武川睦寛
    • Organizer
      第9回CBMS発表会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
  • [Presentation] TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis2016

    • Author(s)
      武川睦寛
    • Organizer
      第一回RNA顆粒/RNAタンパク質複合体研究会
    • Place of Presentation
      岡崎コンファレンスセンター(岡崎)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] MAPキナーゼ情報伝達経路の活性制御機構と疾患2016

    • Author(s)
      武川睦寛
    • Organizer
      東京医科歯科大学大学院セミナー
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Identification of a novel gene that is induced by hyperactivation of the ERK pathway2016

    • Author(s)
      Yusuke Takagi, Yuji Kubota, Masaaki Oyama, Hiroko Kozuka-Hata, Mutsuhiro Takekawa
    • Organizer
      医科学研究所創立記念研究発表会
    • Place of Presentation
      医科学研究所創立記念研究発表会
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of a novel redox-sensor that mediates activation of stress-responsive MAPK pathways2016

    • Author(s)
      Moe Matsushita, Takanori Nakamura and Mutsuhiro Takekawa
    • Organizer
      医科学研究所創立記念研究発表会
    • Place of Presentation
      医科学研究所創立記念研究発表会
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report
  • [Presentation] MAPキナーゼ情報伝達経路の活性制御機構と疾患2016

    • Author(s)
      武川睦寛
    • Organizer
      第53回日本臨床分子医学会学術集会シンポジウム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ERK経路の異常活性化により発現変化する新規遺伝子の機能解析2016

    • Author(s)
      高木祐輔、久保田裕二、川邊庸介、武川睦寛
    • Organizer
      第53回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規ERK応答性non-coding RNAの同定およびその機能解析2016

    • Author(s)
      川邊庸介、久保田裕二、武川睦寛
    • Organizer
      第53回日本臨床分子医学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Remarks] http://www.ims.u-tokyo.ac.jp/dcsmm/DCSMM/Top.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学医科学研究所分子シグナル制御分野ホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/dcsmm/DCSMM/Top.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-06-07  

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