| Project/Area Number |
16K15223
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
OKUDA AKIHIKO 埼玉医科大学, 医学部, 教授 (60201993)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生殖細胞 / 減数分裂 / PRC1 / MAX / MGA / ES細胞 / コンディショナルノックアウトマウス / 異所性減数分裂 / Maxノックアウトマウス / Max / 異所性 |
|---|
| Outline of Final Research Achievements |
Germ cells need to disrupt transcription repressing function of PRC1.6 to onset meiosis. In this study, I investigated the molecular bases of impairment of PRC1.6 function. I also tried to examine whether forced disruption of the function of PRC1.6 is accompanied with ectopic onset of meiosis. With these studies, I identified germ cell specific Mga variant which is supposed to disrupt the function of PRC1.6. Furthermore, I observed up-regulation in expression levels of meiosis-related genes in male primordial germ cells by homozygous knockout of Max gene.
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