| Project/Area Number |
16K15230
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHIMIZU Shigeomi 東京医科歯科大学, 難治疾患研究所, 教授 (70271020)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ケミカルバイオロジー / オートファジー / 実験病理学 / Atg5非依存的 |
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| Outline of Final Research Achievements |
Autophagy is a cellular function that degrades subcellular constituents to contribute cellular homeostasis. The defect of alternative autophagy (Atg5-independent autophagy) may cause various diseases, such as anemia, neurodegenerative diseases, dermatitis, and colitis. In this study, we aimed to identify small chemical compounds/natural compounds that activate alternative autophagy and improve various diseases. As a result, we identified three anti-cancer compounds, two anti-polyglutamine disease compounds, and two anti-tauopathy compounds. We also identified two anti-fatty liver natural compounds.
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