Role of amino acid metabolism in the regulation of inflammation
Project/Area Number |
16K15234
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
AOE Seiichiro 大妻女子大学, 家政学部, 教授 (90365049)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | アミノ酸 / マクロファージ / 炎症 / セリン / 炎症性サイトカイン |
Outline of Final Research Achievements |
Accumulating evidence has suggested that overnutrition-induced chronic inflammation plays an important role in the pathophysiology of the metabolic syndrome. As a molecular basis of chronic inflammation in the metabolic syndrome, sustained complex interaction between parenchymal and stromal cells results in tissue fibrosis, thereby leading to organ dysfunction. However, little is known about the molecular mechanism underlying metabolic stress-induced chronic inflammatory changes in macrophages. In this study, we tried to elucidate the role of serine metabolism in the regulation of macrophage function. Our data showed that serine metabolism is a novel mechanism of inflammatory cytokine production in macrophages.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.2017
Author(s)
Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.
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Journal Title
EBioMedicine
Volume: 18
Pages: 118-27
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis.2017
Author(s)
C. Komiya, M. Tanaka, K. Tsuchiya, N. Shimazu, K. Mori, S. Furuke, Y. Miyachi, K. Shiba, S. Yamaguchi, K. Ikeda, K. Ochi, K. Nakabayashi, K. Hata, M. Itoh, T. Suganami, Y. Ogawa.
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Journal Title
Sci. Rep.
Volume: 7
Issue: 1
Pages: 44754-44754
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016
Author(s)
R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 28845-28845
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inflammatory responses increase secretion of MD-1 protein.2016
Author(s)
RT. Jennings, E. Odkhuu, A. Nakashima, N. Morita, T. Kobayashi, I. Yamai, M. Tanaka, T. Suganami, S. Haga, M. Ozaki, Y. Watanabe, Y. Nagai, K. Takatsu, T. Kikuchi-Ueda, I. Ichimonji, Y. Ogawa, H. Takagi, T. Yamazaki, K. Miyake, S. Akashi-Takamura.
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Journal Title
Int. Immunol.
Volume: 28
Pages: 503-512
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 脂肪組織の慢性炎症2016
Author(s)
菅波孝祥、田中 都、伊藤美智子、小川佳宏
Organizer
第59回日本糖尿病学会年次学術集会
Place of Presentation
京都
Year and Date
2016-05-19
Related Report
Invited
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