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Does NANOG have the potential to regulate immune escape of cancer stem cells?

Research Project

Project/Area Number 16K15236
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionOsaka University

Principal Investigator

Kaneda Yasufumi  大阪大学, 医学系研究科, 教授 (10177537)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌幹細胞 / Nanog / NK細胞 / がん幹細胞 / ICAM-1 / Nk細胞 / 癌
Outline of Final Research Achievements

In cancer stem-like cells, high expression of Nanog and low expression of ICAM-1 were discovered. Nanog expression inhibited ICAM-1 expression in cancer cells, which suppressed the sensitivity of cancer cells to NK cells. Xenograft experiments were performed in SCID mice using cancer cells with Nanog-overexpression or Nanog suppression by Nanog shRNA. It was concluded that Nanog expression accelerated tumor growth in mice by lowering NK cell sensitivity through the suppression of ICAM-1. ChIP seq analysis revealed that Nanog bound to the ICAM-1 promoter sited and inhibited the association of histone acetylase p300 with ICAM-1 promoter. Clinical sample analysis demonstrated the inverse correlation of Nanog and ICAM-1 expression.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Inactivated Sendai Virus Particles upregulate cancer cell ICAM-1 expression with enhancing NK cell sensitivity on cancer cell.2017

    • Author(s)
      Simin, L., Nishikawa, T., Kaneda, Y.
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 12 Pages: 2333-2341

    • DOI

      10.1111/cas.13408

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salmonella mediated the hemagglutinating virus of Japan-envelope transfer suppresses tumor growth.2017

    • Author(s)
      Lee C-H, Nishikawa, T., Kaneda, Y.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 21 Pages: 35048-35060

    • DOI

      10.18632/oncotarget.17037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phase I/II clinical trial to assess safety and efficacy of intratumoral and subcutaneous injection of HVJ-E to castration resistant prostate cancer patients.2017

    • Author(s)
      Fujita, K., Nakai, Y., Kawashima, A., Ujike, T., Nagahara, A., Uemura, M., Miyagawa Y., Lee, C-M., Inoue, T., Kaneda, Y., Nonomura, I.
    • Journal Title

      Cancer Gene Therapy

      Volume: 24 Issue: 7 Pages: 277-281

    • DOI

      10.1038/cgt.2017.15

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development.2016

    • Author(s)
      Nimura K, Yamamoto M, Takeichi M, Saga K, Takaoka K, Kawamura N, Nitta H, Nagano H, Ishino S, Tanaka T, Schwartz RJ, Aburatani H, Kaneda Y.
    • Journal Title

      Elife.

      Volume: 22;5 Pages: 1-20

    • DOI

      10.7554/elife.16030

    • NAID

      120006976062

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Clinical trials for the treatment of intractable cancers using HVJ envelope (HVJ-E).2017

    • Author(s)
      Kaneda, Y.
    • Organizer
      第76回日本癌学会学術総会,
    • Related Report
      2017 Annual Research Report
  • [Presentation] Current status and future prospect of gene therapy in Japan.2017

    • Author(s)
      Kaneda, Y.
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Current status and future prospect of human gene therapy2017

    • Author(s)
      Kaneda, Y.
    • Organizer
      国際胎児新生児治療学会2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 世界の遺伝子治療の現状と展望2017

    • Author(s)
      金田安史
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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