Secretory Transcribed-ultraconserved regions in gastrointestinal and urological cancers and their application to liquid biopsy
Project/Area Number |
16K15247
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Human pathology
|
Research Institution | Hiroshima University |
Principal Investigator |
YASUI WATARU 広島大学, 医歯薬保健学研究科(医), 教授 (40191118)
|
Co-Investigator(Renkei-kenkyūsha) |
OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 分泌型T-UCR / 非翻訳RNA / 消化管癌 / 泌尿器癌 / リキッドバイオプシー / 胃癌・大腸癌 / 腎細胞癌 / UC.63+ / Uc.416+A |
Outline of Final Research Achievements |
Up-regulated transcribed ultraconserved region (T-UCR) transcripts in gastrointestinal cancers and urological cancers, such as U.63+, Uc.416+A, were found to be caidiate marker for liquid biopsy. Concerning prostate cancer, Uc.416+A in the blood was significantly higher in cases with metastases, with castration resistance (CRPC), and with docetaxel resistance. We also identified that Uc.249+A, Uc.266+A, etc. might regulate cancer stem cell properties of colorectal cancer.
|
Report
(3 results)
Research Products
(30 results)
-
-
-
[Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.2017
Author(s)
Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
-
Journal Title
J Pathol
Volume: 243
Issue: 1
Pages: 100-110
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Overexpression of transmembrane protein BST2, participating in cell growth, is associated with poor survival in patients with esophageal, gastric and colorectal cancer2016
Author(s)
Mukai S, Oue N, Oshima T, Tatsumoto Y, Sakamoto N, Sentani N, Hinoi T, Ohdan H, Yasui W
-
Journal Title
Annals of Surgical Oncology
Volume: 24
Issue: 2
Pages: 594-602
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-