| Project/Area Number |
16K15247
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YASUI WATARU 広島大学, 医歯薬保健学研究科(医), 教授 (40191118)
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| Co-Investigator(Renkei-kenkyūsha) |
OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分泌型T-UCR / 非翻訳RNA / 消化管癌 / 泌尿器癌 / リキッドバイオプシー / 胃癌・大腸癌 / 腎細胞癌 / UC.63+ / Uc.416+A |
|---|
| Outline of Final Research Achievements |
Up-regulated transcribed ultraconserved region (T-UCR) transcripts in gastrointestinal cancers and urological cancers, such as U.63+, Uc.416+A, were found to be caidiate marker for liquid biopsy. Concerning prostate cancer, Uc.416+A in the blood was significantly higher in cases with metastases, with castration resistance (CRPC), and with docetaxel resistance. We also identified that Uc.249+A, Uc.266+A, etc. might regulate cancer stem cell properties of colorectal cancer.
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