| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
I revealed that a small G protein Arl8b is associated with TLR7 and regulates TLR7 function. So, I analyzed several SLE mouse models. In some SLE mouse models, I analyzed the role of Arl8b on MRL/lpr mouse model. I observed that Arl8b plays an essential role for the development of SLE in this model. Because MRL/lpr mouse model is not much dependent on TLR7 function, I analyzed carefully TLR7 independent mechanism. I observed that regulatory T cells significantly increased in spleen of MRL/lpr Arl8b deficient mice compared with MRL/lpr wild type mice. IL-2 controls regulatory T cells. I observed IL-2 receptor expression level in spleen of MRL/lpr Arl8b deficient mouse. I found that IL-2 receptor expression level is significantly high on MRL/lpr Arl8b deficient T cells. I will analyze the role of Arl8b for IL-2 receptor expression and controlling regulatory T cell.
|
