• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigating regulatory T cells in skin rare cancer to predict effectiveness of a new immunotherapy

Research Project

Project/Area Number 16K15259
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

Yamazaki Sayuri  名古屋市立大学, 大学院医学研究科, 教授 (70567255)

Co-Investigator(Kenkyū-buntansha) 小田中 瑞夕  名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
今井 優樹  名古屋市立大学, 大学院医学研究科, 講師 (30440936)
Co-Investigator(Renkei-kenkyūsha) MORITA Akimichi  名古屋市立大学, 大学院医学研究科, 教授 (30264732)
OHKURA Naganari  大阪大学, 医学(系)研究科(研究院), 教授 (20300949)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords制御性T細胞 / 皮膚希少癌 / 皮膚稀少癌 / 免疫学
Outline of Final Research Achievements

Immune checkpoint inhibitors such as anti-CTLA-4 Ab and anti-PD1 Ab are now available for melanoma, which is effective for some patients. We conducted this research to provide data that these immunotherapies can be also effective for skin rare cancers and other cancers that are not yet approved for the use of immune checkpoint inhibitors. First we determined sampling conditions such as usage of enzymes to digest tumors because samples were very valuable. We found that regulatory T cells infiltrated into skin rare cancers and other cancers by flowcytometry. We also found that the regulatory T cells expressed specific gene expression patterns.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] NAZARBAYEV UNIVERSITY(カザフスタン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] TLRアゴニストを用いた抗癌免疫アジュバント療法2018

    • Author(s)
      志馬寛明、松本美佐子、山崎小百合、瀬谷司
    • Journal Title

      Thrombosis Medicine

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin2017

    • Author(s)
      Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
    • Journal Title

      The Journal of Immunology

      Volume: 200 Issue: 1 Pages: 119-129

    • DOI

      10.4049/jimmunol.1701056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis2017

    • Author(s)
      Ryoji Kubo, Shinnosuke Muramatsu, Yoko Sagawa, Chiyo Saito, Saori Kasuya, Akiko Nishioka, Emi Nishida, Sayuri Yamazaki, Akimichi Morita
    • Journal Title

      Journal of Dermatological Science

      Volume: 86 Issue: 1 Pages: 46-53

    • DOI

      10.1016/j.jdermsci.2017.01.001

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 制御性T細胞の恒常性と皮膚2016

    • Author(s)
      山崎小百合, 森田明理
    • Journal Title

      臨床皮膚科臨時増刊号

      Volume: 5 Pages: 39-41

    • Related Report
      2016 Research-status Report
  • [Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure2017

    • Author(s)
      Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A.
    • Organizer
      LC2017 15th International Workshop on Langerhans Cells. NewYork, USA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does Juzen-Taiho-Tohave immunosuppressive effect?2016

    • Author(s)
      Ken Kanno, Mizuyu Odanaka, Masaki Imai, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県、宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] The complement anaphylatoxin C5ades Arg still induce the acute inflammatory responce2016

    • Author(s)
      Masaki IMAI, Mizuyu ODANAKA, Shoryu TAKAYAMA,Rieko Ohta, Sayuri YAMAZAKI
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ultraviolet B exposure expands skin-homing receptor+ Foxp3+CD4+ regulatory T cells in the skin2016

    • Author(s)
      Mizuyu Odanaka, Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Osamu Taguchi, Masaki Imai, Akimichi Morita
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Does Juzen-Taiho-To show therapeutic effect in Imiquimod-induced psoriatic mice?2016

    • Author(s)
      Ken Kanno, Masaki Imai, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
    • Organizer
      Cold Spring Harbor Conference Asia
    • Place of Presentation
      Awaji(Japan)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 樹状細胞と制御性T細胞を利用した 免疫制御と治療2016

    • Author(s)
      山崎小百合
    • Organizer
      愛知医科大学 特別講演
    • Place of Presentation
      愛知医科大学(愛知県、長久手市)
    • Year and Date
      2016-10-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Ultraviolet B Expands Skin-Homing Thymus-derived Foxp3+ CD4+ Regulatory T Cells2016

    • Author(s)
      Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya,Masaki Imai, Osamu Taguchi, Akimichi Morita
    • Organizer
      Cold Spring Harbor Conference Gene Expression& Signaling in the Immune System
    • Place of Presentation
      NewYork(U.S.A)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 名古屋市立大学大学院医学研究科免疫学分野

    • URL

      http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科免疫学

    • URL

      http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi