Investigating regulatory T cells in skin rare cancer to predict effectiveness of a new immunotherapy
| Project/Area Number |
16K15259
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Yamazaki Sayuri 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
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| Co-Investigator(Kenkyū-buntansha) |
小田中 瑞夕 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Akimichi 名古屋市立大学, 大学院医学研究科, 教授 (30264732)
OHKURA Naganari 大阪大学, 医学(系)研究科(研究院), 教授 (20300949)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 制御性T細胞 / 皮膚希少癌 / 皮膚稀少癌 / 免疫学 |
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| Outline of Final Research Achievements |
Immune checkpoint inhibitors such as anti-CTLA-4 Ab and anti-PD1 Ab are now available for melanoma, which is effective for some patients. We conducted this research to provide data that these immunotherapies can be also effective for skin rare cancers and other cancers that are not yet approved for the use of immune checkpoint inhibitors. First we determined sampling conditions such as usage of enzymes to digest tumors because samples were very valuable. We found that regulatory T cells infiltrated into skin rare cancers and other cancers by flowcytometry. We also found that the regulatory T cells expressed specific gene expression patterns.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure2017
Author(s)
Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A.
Organizer
LC2017 15th International Workshop on Langerhans Cells. NewYork, USA
Related Report
Int'l Joint Research
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