| Project/Area Number |
16K15277
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Okayama University |
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Principal Investigator |
Ohara Naoya 岡山大学, 医歯薬学総合研究科, 教授 (70223930)
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| Co-Investigator(Kenkyū-buntansha) |
中山 真彰 岡山大学, 医歯薬学総合研究科, 助教 (10579105)
大原 直子 岡山大学, 大学病院, 講師 (80301365)
橘 理人 岡山大学, 医歯薬学総合研究科, 助教 (20636831)
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| Research Collaborator |
KOSAKI Hirotaka
RYUMON Ayako
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マイコバクテリウム / 増殖 / 葉酸代謝 / 結核 / BCG / 細菌 / 増殖速度 |
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| Outline of Final Research Achievements |
Mycobacterium tuberculosis is an intracellular pathogen, has a remarkably slow growth rate, and survives long periods of time in the host. We found that overexpression of thyX in BCG (pthyX) resulted in accelerating its growth rate. We analyzed the gene expression profiles in pthyX using RNAseq. Several genes in folate metabolism pathway were up-ragulated in pthyX. We concluded that tetrahydrofolate is the key molecule in the control of the growth rate of slow-growing mycobacteria.
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