Reinvestigating HIV-specific effector cells targeting latent reservoir cells
Project/Area Number |
16K15284
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | Kumamoto University |
Principal Investigator |
UENO Takamasa 熊本大学, エイズ学研究センター, 准教授 (10322314)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | HIV/AIDS / HIV / ウイルス / 感染症 / 免疫学 |
Outline of Final Research Achievements |
Although the antiretroviral therapy successfully prolongs lives of HIV-infected patients, the current therapy is insufficient to eradicate infected cells. Exploring new type of antiviral effector cells that specifically eradicate HIV-infected cells is warranted. In this study, we sought to establish novel assay systems for antiviral effector cells and proceed functional screening using previously frozen cells that had been analyzed for nonfunctioning when tested other purposes. Although we have succeeded in establishing some new assay systems, we could not find novel type of effector cells harboring strong antiviral effector functions.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018
Author(s)
F Mwimanzi, M Toyoda, M Mahiti, J Mann, J Martin, D Bangsberg, M Brockman, P Goulder, F Kirchhoff, Z Brumme, T Ndung’u, T Ueno
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Journal Title
Journal of Virology
Volume: 92
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Relative resistance of HLA-B to down-regulation by naturally occurring HIV-1 Nef sequences2016
Author(s)
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D Walker, Yong Xiong, Zabrina L Brumme, Mark A Brockman, Takamasa Ueno
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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