• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Control of dynamics and function of T cells by glucocorticoids via IL-7 receptor expression

Research Project

Project/Area Number 16K15288
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

Ikuta Koichi  京都大学, ウイルス・再生医科学研究所, 教授 (90193177)

Co-Investigator(Kenkyū-buntansha) 谷一 靖江  京都大学, 医学研究科, 助教 (50432331)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsステロイド / T細胞 / IL-7 / 概日リズム / 内分泌系 / 適応免疫 / 糖質コルチコイド / 免疫学 / 内科 / 感染症 / 生理学
Outline of Final Research Achievements

Glucocorticoids are a group of steroid hormones with strong anti-inflammatory and immunosuppressive effects. However, the physiological function of glucocorticoids in the immune system remains largely unclear. We found that the glucocorticoid receptor induces IL-7 receptor (IL-7R) expression in T cells by binding to the enhancer of the IL-7R locus, and that the induction followed diurnal rhythm of glucocorticoid concentration. The diurnal expression of IL-7R supported T cell survival and triggered T cell redistribution between lymph nodes, spleen, Peyer’s patches and blood by inducing the chemokine receptor, CXCR4. CXCR4 induction triggered T cell migration to spleen and Peyer’s patches. Consequently, T cell accumulation in spleen promoted immune responses against systemic bacterial infection and antigen administration. Our study reveals the immunoenhancing role of glucocorticoids, and provides insights how the immune function is controlled by the diurnal rhythm.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 5 results) Remarks (3 results)

  • [Int'l Joint Research] Kantonsspital St. Gallen/Heinrich Heine University/University of Bern, Bern(スイス、ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Yale University/German Cancer Research Center/University of Leuven(米国、ドイツ、ベルギー)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR42018

    • Author(s)
      Shimba A, Cui G, Tani-Ichi S, Ogawa M, Abe S, Okazaki F, Kitano S, Miyachi H, Yamada H, Hara T, Yoshikai Y, Nagasawa T, Schütz G, Ikuta K.
    • Journal Title

      Immunity

      Volume: 48 Issue: 2 Pages: 286-298

    • DOI

      10.1016/j.immuni.2018.01.004

    • NAID

      120006401712

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells2017

    • Author(s)
      Nakamizo Satoshi、Honda Tetsuya、Adachi Akimasa、Nagatake Takahiro、Kunisawa Jun、Kitoh Akihiko、Otsuka Atsushi、Dainichi Teruki、Nomura Takashi、Ginhoux Florent、Ikuta Koichi、Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 999-999

    • DOI

      10.1038/s41598-017-14292-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sepsis-induced osteoblast ablation causes immunodeficiency2016

    • Author(s)
      Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K. and Takayanagi, H.
    • Journal Title

      Immunity

      Volume: 44 Issue: 6 Pages: 1434-1443

    • DOI

      10.1016/j.immuni.2016.05.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation2016

    • Author(s)
      Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 113 Issue: 20

    • DOI

      10.1073/pnas.1512600113

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fibroblastic reticular cells regulate intestinal inflammation through IL-15-mediated control of group 1 ILCs2016

    • Author(s)
      Gil-Cruz, C., Perez-Shibayama, C., Onder, L., Chai, Q., Cupovic, J., Cheng, H., Novkovic, M., Lang, P. A., Geuking, M. B., McCoy, K. D., Abe, S., Cui, G., Ikuta, K., Scandella, E., and Ludewig, B.
    • Journal Title

      Nat. Immunol.

      Volume: 17 Issue: 12 Pages: 1388-1396

    • DOI

      10.1038/ni.3566

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation2016

    • Author(s)
      Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
    • Journal Title

      Immunity

      Volume: 45 Issue: 6 Pages: 1219-1231

    • DOI

      10.1016/j.immuni.2016.11.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Glucocorticoids drive circadian changes in T-cell homing and response via IL-7 receptor2017

    • Author(s)
      Shimba, A., and Ikuta, K.
    • Organizer
      Immunology 2017 (AAI)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-7Rα signaling upregulates growth hormone signaling-related gene in naive T cells2017

    • Author(s)
      Tani-ichi, S., and Ikuta, K.
    • Organizer
      Keystone Symposium: Integrating Metabolism and Immunity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Osteoblasts mediate immunosuppression during sepsis by regulating lymphopoiesis2017

    • Author(s)
      Terashima, A., Okamoto, K., Nakashima, T., Ikuta, K., and Takayanagi, H.
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グルココルチコイドはIL-7受容体の発現を介してT細胞の体内分布および活性化の日内変動を制御する2017

    • Author(s)
      岡崎史恵、榛葉旭恒、崔広為、生田宏一
    • Organizer
      ConBio2017(生命科学系学会合同年次大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7 receptor expression2017

    • Author(s)
      Shimba, A., Cui, G., and Ikuta, K.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Competition between STAT5 and PI3K of the IL-7R modulates T cell and type 2 ILC development in vivo2017

    • Author(s)
      Cui, G., Shimba, A., Zhu, Y., Tani-ichi, S., Hara, T., and Ikuta, K.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Exploring the signals upregulating IL-7Rα expression via NFκB activation in T cells2017

    • Author(s)
      Tani-ichi, S., and Ikuta, K.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of IL-7 receptor expression by a proximal enhancer2017

    • Author(s)
      榛葉旭恒、崔広為、谷一靖江、原崇裕、生田宏一
    • Organizer
      KTCC 2017
    • Place of Presentation
      芝蘭会館、京都
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of glucocorticoids in T cell homeostasis and T cell response2016

    • Author(s)
      榛葉旭恒、崔広為、阿部真也、朱媛博、向平妃沙、谷一靖江、原崇裕、生田宏一
    • Organizer
      The 23rd East Asia Joint Symposium
    • Place of Presentation
      台北、台湾
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] ステロイドが免疫力を高める?! -免疫の新たな昼夜サイクルを解明 -

    • URL

      http://www.infront.kyoto-u.ac.jp/achievements/post-2986/

    • Related Report
      2017 Annual Research Report
  • [Remarks] ステロイドが免疫力を高める -免疫の新たな昼夜サイクルを解明-

    • URL

      http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180124_1.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 多能性造血前駆細胞からリンパ球までの分化を方向付ける骨髄ニッチの同定

    • URL

      http://www.infront.kyoto-u.ac.jp/achievements/post-1160/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi