| Project/Area Number |
16K15290
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Hisashi Arase 大阪大学, 微生物病研究所, 教授 (10261900)
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| Co-Investigator(Renkei-kenkyūsha) |
KISHIDA Kazuki 大阪大学, 微生物病研究所, 特任研究員 (90755662)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 免疫制御 / 抗体 / MHC |
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| Outline of Final Research Achievements |
MHC class II molecules play an important role by presenting peptides to helper T cells. We have found that antibodies against peptide/MHC class II complex are produced during immune response. In this study, we analyzed the anti-peptide/MHC class II complex antibodies. We found that anti-peptide/MHC class II complex antibodies are produced by specific peptide sequence, block T cell response and suppress autoimmune diseases. These findings suggested that anti-peptide/MHC class II complex antibodies play an important role by suppressing T cell response.
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