Antigen-specific regulation of T cell response by anti-MHC antibodies
| Project/Area Number |
16K15290
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Hisashi Arase 大阪大学, 微生物病研究所, 教授 (10261900)
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| Co-Investigator(Renkei-kenkyūsha) |
KISHIDA Kazuki 大阪大学, 微生物病研究所, 特任研究員 (90755662)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 免疫制御 / 抗体 / MHC |
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| Outline of Final Research Achievements |
MHC class II molecules play an important role by presenting peptides to helper T cells. We have found that antibodies against peptide/MHC class II complex are produced during immune response. In this study, we analyzed the anti-peptide/MHC class II complex antibodies. We found that anti-peptide/MHC class II complex antibodies are produced by specific peptide sequence, block T cell response and suppress autoimmune diseases. These findings suggested that anti-peptide/MHC class II complex antibodies play an important role by suppressing T cell response.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Novel autoantibody against the β2-glycoprotein I/human leucocyte antigen-DR complex in patients with refractory cutaneous ulcers.2018
Author(s)
Arase N, Tanimura K, Jin H, Yamaoka T, Kishibe M, Nishioka M, Kiyohara E, Tani M, Matsuoka S, Ohmura K, Takasugi K, Yamamoto T, Murota H, Arase H, Katayama I.
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Journal Title
British Journal of Dermatology
Volume: 印刷中
Pages: 272-275
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors2017
Author(s)
Saito Fumiji、Hirayasu Kouyuki、Satoh Takeshi、Wang Christian W.、Lusingu John、Arimori Takao、Shida Kyoko、Palacpac Nirianne Marie Q.、Itagaki Sawako、Iwanaga Shiroh、Takashima Eizo、Tsuboi Takafumi、Kohyama Masako、Suenaga Tadahiro、Colonna Marco、Takagi Junichi、Lavstsen Thomas、Horii Toshihiro、Arase Hisashi
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Journal Title
Nature
Volume: 552
Pages: 101-105
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Antiphospholipid antibody recognizes β2GPI complexed with HLA class II molecules via its domain V2017
Author(s)
Yuki Sasagawa, Kenji Tanimura, Hui Jin, Noriko Arase, Tadahiro Suenaga, Masako Kohyama, Kouyuki Hirayasu, Satoko Morikami, Yasuhiko Ebina, Tatsuya Atsumi, Hideto Yamada, Hisashi Arase
Organizer
第46回日本免疫学会学術集会
Related Report
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