Regulation of B-cell memory formation by metabolic programs
Project/Area Number |
16K15295
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Tokyo University of Science |
Principal Investigator |
Kitamura Daisuke 東京理科大学, 研究推進機構生命医科学研究所, 教授 (70204914)
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Co-Investigator(Renkei-kenkyūsha) |
HANIUDA Kei 東京理科大学, 研究推進機構生命医科学研究所, 助教 (40734918)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 胚中心 / メモリーB細胞 / ミトコンドリア代謝 / 解糖系 / BCL6 / プラズマ細胞 / B細胞 / 免疫記憶 |
Outline of Final Research Achievements |
During immune responses, antigen-responding B cells are activated and form germinal centers (GC) in the lymphoid organs. The GC B cells undergo somatic hypermutation in their immunoglobulin genes encoding B-cell receptors (BCR), and diversify the BCR affinity to antigen. High affinity B cells are then selected in the GC through T-cell help and finally differentiate into memory B cells. Memory B cells have abilities to survive for a long time and to rapidly respond to antigen to proliferate and differentiate into plasma cells. In this study, we elucidated mechanisms for how GC B cells maintain proliferation and how memory B cells live long and respond rapidly in terms of mitochondrial and glycolysis metabolisms, utilizing our original methodology, the induced GC B (iGB) cell culture system.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Cbl ubiquitin ligases control B cell exit from the germinal-center reaction.2018
Author(s)
Li, X., Gadzinsky, A., Gong, L., Tong, H., Calderon, V., Li, Y., Kitamura, D., Klein, U., Langdon, W.Y., Hou, F., Zou, Y.R. and Gu, H.
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Journal Title
Immunity
Volume: 48
Issue: 3
Pages: 530-541
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Host DNases prevent vascular occlusion by neutrophil extracellular traps2017
Author(s)
Jimenez-Alcazar Miguel、Rangaswamy Chandini、Panda Rachita、Bitterling Josephine、Simsek Yashin J.、Long Andy T.、Bilyy Rostyslav、Krenn Veit、Renn? Christoph、Renn? Thomas、Kluge Stefan、Panzer Ulf、Mizuta Ryushin、Mannherz Hans Georg、Kitamura Daisuke、Herrmann Martin、Napirei Markus、Fuchs Tobias A.
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Journal Title
Science
Volume: 358
Issue: 6367
Pages: 1202-1206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] BCR and endosomal TLR signals synergize to increase AID expression and establish central B cell tolerance.2017
Author(s)
Kuraoka, M., Snowden, P.B., Nojima, T., Verkoczy, L., Haynes, B.F., Kitamura, D., Kelsoe, G.
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Journal Title
Cell Reports
Volume: 18
Issue: 7
Pages: 1627-1635
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differing requirements for MALT1 function in peripheral B cell survival and differentiation.2017
Author(s)
Lee, P., Zhu, Z., Hachmann, J., Nojima, T., Kitamura, D., Salvesen, G., Rickert, R.C.
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Journal Title
The Journal of Immunology
Volume: 198
Issue: 3
Pages: 1066-1080
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells.2016
Author(s)
Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., Mizuta, R.
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Journal Title
Genes to Cells
Volume: 21
Issue: 11
Pages: 1150-1163
DOI
Related Report
Peer Reviewed
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[Journal Article] IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.2016
Author(s)
Domeier, P.P., Chodisetti, S.B., Soni, C., Schell, S.L., Elias, M.J., Wong, E.B., Cooper, T.K., Kitamura, D., Rahman, Z.S.
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Journal Title
Journal of Experimental Medicine
Volume: 213
Issue: 5
Pages: 715-732
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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