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Regulation of influenza protective antibody responses by microbiota

Research Project

Project/Area Number 16K15296
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Takahashi Yoshimasa  国立感染症研究所, 免疫部, 部長 (60311403)

Co-Investigator(Kenkyū-buntansha) 八村 敏志  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40238019)
Co-Investigator(Renkei-kenkyūsha) Onodera Taishi  国立感染症研究所, 免疫部, 主任研究官 (90513143)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインフルエンザ / 腸内細菌 / B細胞 / 抗体 / 免疫学
Outline of Final Research Achievements

In this study, we have investigated cross-reactivity of influenza hemagglutinin-binding monoclonal antibody panel to microbiota and identified several HA-binding monoclonal antibodies that are reactive to particular microbiota. Germline-reverted forms of antibodies possessed the cross-reactivity, indicating that the reactivity was already acquired in pre-immune status. Removal of microbiota using germ-free mice or antibiotics-treated mice elucidated the possible links between antigen-driven B cell development and microbiota. Thus, microbiota shapes the antibody repertoires to influenza viruses in both pre-immune and post-immune status.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Acknowledgement Compliant: 3 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Role of germinal centers for the induction of broadly-reactive memory B cells.2017

    • Author(s)
      Takahashi Y, Kelsoe G
    • Journal Title

      Current Opinion in Immunology

      Volume: 45 Pages: 119-125

    • DOI

      10.1016/j.coi.2017.03.002

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Protective neutralizing influenza antibody response in the absence of T follicular helper cells2016

    • Author(s)
      Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M
    • Journal Title

      Nature Immunology

      Volume: 17(12) Issue: 12 Pages: 1447-1458

    • DOI

      10.1038/ni.3563

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulated selection of germinal center cells into the memory B cell compartment.2016

    • Author(s)
      Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki,T.
    • Journal Title

      Nat. Immunol.

      Volume: 17 Issue: 7 Pages: 861-9

    • DOI

      10.1038/ni.3460

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Influenza hemagglutinin epitopes emerging at viral replication sites promote the clonal selection and plasma cell development of broadly protective B cells.2017

    • Author(s)
      Adachi, Y., Nithichanon, A., Kuraoka, M., Kelsoe, G., Ato, M., Takahashi, Y.
    • Organizer
      Keystone symposia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of broadly-protective B cell responses to mutating viruses.2017

    • Author(s)
      Takahashi, Y.
    • Organizer
      第46回日本免疫学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Regulation of antibody breadth to mutating viruses through distinct germinal center selection.2017

    • Author(s)
      Takahashi, Y., Adachi, Y., Onodera, T., Ato, M.
    • Organizer
      The 16th Awaji International Forum on Infection and Immunity
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Broadly cross-reactive human memory B cells against norovirus express dual B cell antigen receptors.2016

    • Author(s)
      Onodera T, Ato M, Takahashi T
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Related Report
      2016 Research-status Report
  • [Presentation] Different accessibility of strain-specific versus cross-reactive BCRs to virus particles regulates site-specific germinal center selection.2016

    • Author(s)
      Adachi Y, Ato M, Takahashi Y
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Related Report
      2016 Research-status Report
  • [Presentation] Follicular helper NKT cells induce protective effect of a protein-based pneumococcal vaccine through stimulation of IgG production by B cells.2016

    • Author(s)
      Nakahara M, Takatsuka S, Ueno K, Onodera T, Takahashi Y, Kawakami K, Kubo M, Kinjo Y
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Related Report
      2016 Research-status Report
  • [Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      高橋宜聖
    • Total Pages
      6
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] MODIFIED H7 HEEMAGULUTTININ GLYCOPAROTEIN OF THE INFLUENZA A/SHANGHAI/2/2013 H7 SEQUENSE(インフルエンザ A/Shanghai/2/2013 H7ヘマグルチニン糖蛋白の修飾アミノ酸配列)2016

    • Inventor(s)
      Anne S De Groot 他3名
    • Industrial Property Rights Holder
      Anne S De Groot 他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-15
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2016-04-21   Modified: 2019-03-29  

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