| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
This research project was aimed to investigate the mechanism by which molecular hydrogen (H2) has a potential to accelerate the beta-receptor signal. The real-time measurement system of intracellular cAMP was employed to evaluate the receptor signal. H2 showed synergistic action on the beta and calcitonin receptors, respectively. The site of action was indicated on the receptor. However, the fact that the effective range of H2 was extremely narrow suggests the requirement of a delicate control system of H2 to appreciate H2 actions. The effect of H2 on the receptor is slight compared to other pharmaceutical drugs.
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