Development of probes for cancer theranostics based on photoacoustic effect and application for innovative DDS

Research Project

Project/Area Number	16K15316
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Applied pharmacology
Research Institution	Kobe Pharmaceutical University
Principal Investigator	Sano Kohei 神戸薬科大学, 薬学部, 講師 (00546476)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ドラッグデリバリー / 光音響 / セラノスティックス
Outline of Final Research Achievements	In order to　develop　molecular　probes　enabling　cancer-targeted　photoacoustic imaging and cancer therapy, we newly synthesized trastuzumab (anti-HER2 monoclonal antibody)-conjugated liposome containing iron oxide nanoparticles (IONP) (Tra-IONP-liposome). The observation using transmission electron microscopy revealed many IONPs were encapsulated in the aqueous phase of liposomes. The Tra-IONP-liposome exhibited the intense photoacoustic signals, and could bind HER2-positive cancer cells HER2-specifically. Furthermore, this probe produced heat enough for cytotoxicity effect by irradiation of near-infrared light.