Treatment strategy for kidney disease based on TLR4-macrophage control by alfa1-acid glycoprotein
| Project/Area Number |
16K15320
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小田切 優樹 崇城大学, 薬学部, 教授 (80120145)
丸山 徹 熊本大学, 薬学部, 教授 (90423657)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | alfa1-acid glycoprotein / kidney disease / TLR4 / macrophage / 腎線維化 / ビタミンD / AGP / α1-酸性糖蛋白質 / アドリアマイシン腎障害 / マクロファージ / 糸球体バリア / α1-酸性糖タンパク質 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
Human alfa1-acid glycoprotein (AGP) is known as an acute phase reactant, and we have recently found anti-inflammatory effects of AGP. In this study, the effect of AGP on renal protection on adriamycin-nephropathy (AN) mice was investigated. As a result, administration of AGP to AN mice reduced proteinuria and improved kidney tissue inury. At that time, the expression level of TNF-alfa and macrophage marker F4/80 in the kidney was decreased. Addition of AGP to macrophages resulted in an increase in IL-10 production and a decrease in iNOS expression. At the same time, gene expression of CD 163 also increased. In conclusion, we discovered for the first time that AGP exerts a renoprotective effect through the calming of the inflammatory response caused by macrophages.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Dual therapeutic effects of an albumin-based nitric oxide donor on two experimental models of chronic kidney disease2018
Author(s)
Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T
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Journal Title
J Pharm Sci
Volume: 107
Issue: 3
Pages: 848-855
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism2017
Author(s)
Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Biochem Pharmacol.
Volume: 145
Pages: 192-201
DOI
Related Report
Peer Reviewed
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[Journal Article] The down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism2017
Author(s)
Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura M, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Toru Maruyama
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Journal Title
Kidney Int
Volume: 91
Issue: 3
Pages: 658-670
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-12016
Author(s)
Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 32084-32084
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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