| Project/Area Number |
16K15326
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
Wada Takashi 金沢大学, 医学系, 教授 (40334784)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
古市 賢吾 金沢大学, 附属病院, 准教授 (50432125)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | キラルアミノ酸 / 慢性腎臓病 / バイオマーカー / 臨床検査医学 |
|---|
| Outline of Final Research Achievements |
The number of patients suffering from chronic kidney disease (CKD), which is a risk factor for end-stage kidney disease resulting in requirement for renal replacement therapy is increasing all over the world. To overcome CKD, the establishment of adequate clinico-pathological parameters and related biomarkers for diagnosis and/or prediction for prognoses is required. Recent advances in research have shed light on the chirality of amino acids. The two-dimensional (2D) HPLC technique reveals that free D-amino acids and their L-forms are quantified quantitatively. In this study, we aimed to examine the pathophysiology of kidney diseases depending on amino acids and related relevant biomarker candidates for chronic kidney disease. As a result, we determined biomarker candidates, which were associated with the progression of chronic kidney disease.
|
