• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Attempt at identifying pathogenic antigens of painful autoimmune neuropathy

Research Project

Project/Area Number 16K15339
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionKagoshima University

Principal Investigator

KURIHARA Takashi  鹿児島大学, 医歯学域医学系, 准教授 (60282745)

Co-Investigator(Renkei-kenkyūsha) YUKI Nobuhiro  シンガポール国立大学, 医学部, 前教授 (60285913)
Wilder-Smith Einar P.  シンガポール国立大学, 医学部, 教授
Devaux Jérôme J  エクス=マルセイユ大学, 神経科学研究センター, 主任研究員
Research Collaborator FUKUDOME Gaku  
YOUKAI Masafumi  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords有痛性神経障害 / 自己免疫疾患 / 受動移入 / 脊髄 / 一次知覚神経 / 後根神経節 / 疼痛 / 自己免疫 / 機械的アロディニア / 熱性痛覚過敏
Outline of Final Research Achievements

We present three patients with acute onset and monophasic course of painful neuropathy, who had antecedent infectious symptoms. IgG antibodies in their acute phase sera strongly bound to murine spinal dorsal horn, small neurons in the dorsal root ganglia, and small nerve fibres. Interestingly, the bindings disappeared during the convalescent phase. Furthermore, serum transfer to a mouse nociceptive model induced transient alteration in thermal pain responses. Our case series suggest that an acute transient immune response can be directed against the nociceptive pathway. Although we have still not been able to identify the target antigens, we try to recruit large cohorts of patients to support the identification of the pathogenic antigens in these patients.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (32 results)

All 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (22 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] National University Singapore(Singapore)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Aix-Marseille Universite(France)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome.2018

    • Author(s)
      Yuki N, Chan AC, Wong AHY, Inoue T, Yokai M, Kurihara T, Devaux JJ, Wilder-Smith E.
    • Journal Title

      Muscle & Nerve

      Volume: 57(2) Issue: 2 Pages: 320-324

    • DOI

      10.1002/mus.25738

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In silico screening identified novel small-molecule antagonists of PAC1 receptor.2018

    • Author(s)
      Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa, D, Nagashima, R, Fukuchi, M, Okada, T, Toyooka, N, Miyata, A, Gouda H, Kurihara T.
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: - Issue: 1 Pages: 1-8

    • DOI

      10.1124/jpet.117.245415

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.2017

    • Author(s)
      Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
    • Journal Title

      PLoS One

      Volume: 12(7) Issue: 7 Pages: e0180610-e0180610

    • DOI

      10.1371/journal.pone.0180610

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice2017

    • Author(s)
      Aizawa F, Ogaki Y, Kyoya N, Nishinaka T, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 8 Pages: 1255-1259

    • DOI

      10.1248/bpb.b17-00082

    • NAID

      130005876328

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] FFAR1/GPR40は疼痛遷延化に伴う情動行動変化に関与する2018

    • Author(s)
      水沼亮太、栗原 崇、神戸悠輝、平澤 明、中本賀寿夫、大吉達樹、徳山尚吾、有田和徳、宮田篤郎
    • Organizer
      第138回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 難治性疼痛治療を目指した新規PACAP特異的受容体拮抗薬の開発2018

    • Author(s)
      栗原 崇
    • Organizer
      LIP.横浜 オープンイノベーションカンファレンス2
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗がん剤 (Oxaliplatin) 誘発性末梢神経障害における新規 PAC1 受容体アンタゴニス トの効果2018

    • Author(s)
      上田 隆拡、長島 涼太、渡辺 藍、岡田 卓哉、豊岡 尚樹、髙﨑 一朗、栗原 崇、宮田 篤郎
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脊髄神経結紮モデルマウスの疼痛反応に対する新規 PAC1 受容体拮抗薬の効果2018

    • Author(s)
      下平 文香、長島 涼太、渡辺 藍、岡田 卓哉、豊岡 尚樹、合田 浩明、宮田 篤郎、栗原 崇、髙﨑 一朗
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAP 誘発性疼痛反応における Cyr61-chemokine 経路に関する研究2018

    • Author(s)
      緒方 知輝、前田 辰則、高崎 一朗、宮田 篤郎、栗原 崇
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GPR40/FFAR1は慢性疼痛に伴ううつ病に関与するか?2017

    • Author(s)
      水沼亮太、栗原 崇、神戸悠輝、平澤明、中本賀寿夫、徳山尚吾、宮田篤郎
    • Organizer
      第14回GPCR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAP誘発性疼痛様行動の発症における脊髄アストロサイト-ニューロン乳酸シャトルの関与2017

    • Author(s)
      神戸悠輝、栗原 崇、用皆正文、前田辰則、高﨑一朗、宮田篤郎
    • Organizer
      第14回GPCR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 難治性慢性疼痛治療を目指したPACAP特異的受容体アンタゴニストの開発2017

    • Author(s)
      髙﨑一朗、渡辺 藍、用皆正文、長島涼太、上田隆拡、柴崎知華、岡田卓哉、合田浩明、豊岡尚樹、宮田篤郎、栗原 崇
    • Organizer
      第14回GPCR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAP誘発長期機械的アロディニア現象発症におけるCyr61/CCN1の関与2017

    • Author(s)
      栗原 崇、用皆正文、八坂敏一、神戸悠輝、前田辰則、原 博満、宮田篤郎、高﨑一朗
    • Organizer
      第14回GPCR研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疼痛時における脳内遊離脂肪酸の変化2017

    • Author(s)
      中本賀寿夫、相澤風花、山下琢矢、平澤 明、栗原 崇、宮田篤郎、糟谷史代、徳山尚吾
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GPR40/FFAR1は慢性疼痛に伴ううつ病に関与するか?2017

    • Author(s)
      水沼亮太、栗原 崇、神戸悠輝、平澤明、中本賀寿夫、徳山尚吾、宮田篤郎
    • Organizer
      第10回トランスポーター研究会九州部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 難治性疼痛治療を目指した新規PACAP特異的受容体拮抗薬の開発2017

    • Author(s)
      栗原 崇、渡辺 藍、長島 涼太、上田 隆拡、岡田 卓哉、豊岡 尚樹、宮田 篤郎、合田 浩明、髙﨑 一朗
    • Organizer
      第5回TR推進合同フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] GPR40/FFAR1は慢性疼痛に伴ううつ病に関与するか?2017

    • Author(s)
      水沼亮太、栗原 崇、神戸悠輝、平澤明、中本賀寿夫、大吉達樹、徳山尚吾、有田和徳、宮田篤郎
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] GPR40/FFAR1欠損マウスはコカイン誘発移所運動活性亢進効果が減弱している2017

    • Author(s)
      貞村祐子、栗原 崇、水沼亮太、神戸悠輝、平澤明、中本賀寿夫、大吉達樹、徳山尚吾、有田和徳、宮田篤郎
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAPは脊髄アストロサイト-ニューロン乳酸シャトル(ANLS)を介してマウスの疼痛様行動を惹起する2017

    • Author(s)
      神戸悠輝、栗原 崇、用皆正文、高﨑一朗、宮田篤郎
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規PAC1受容体拮抗薬の開発と疼痛モデルマウスを用いた評価2017

    • Author(s)
      下平文香、長島涼太、上田隆拡、中村晃司、渡辺 藍、岡田卓哉、豊岡尚樹、合田浩明、宮田篤郎、栗原 崇、髙﨑一朗
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PACAPによるアストロサイト-ニューロン乳酸シャトルの活性化と恐怖記憶の獲得・想起への関与2017

    • Author(s)
      中島優、神戸悠輝、Nguyen Thanh Trung、栗原 崇、新谷紀人、橋本均、吉武尚、Jan Kehr、宮田篤郎
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Endogenous PACAP increases food intake by modulating the neuropeptide expression in the hypothalamus2017

    • Author(s)
      Trung N.T., Kambe Y., Kurihara T, Shintani N, Hashimoto H, Miyata A
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] INVOLVEMENT OF SPINAL CYR61/CCN1 IN PACAP-SPECIFIC RECEPTOR-INDUCED LONG-TERM MECHANICAL ALLODYNIA IN MICE2017

    • Author(s)
      Kurihara T., Yokai M., Maeda T., Yasaka T., Hara H., Miyata A. and Takasaki I
    • Organizer
      13th international symposium on VIP, PACAP and related peptides
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DEVELOPMENT OF SMALL-MOLECULE PAC1 RECEPTOR ANTAGONISTS AIMED AT DRUG DISCOVERY OF NOVEL ANALGESICS2017

    • Author(s)
      Takasaki I., Watanabe A., Yokai M., Nagashima R., Ueda T., Gouda H., Toyooka N., Miyata A., and Kurihara T
    • Organizer
      13th international symposium on VIP, PACAP and related peptides
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ASTROCYTE-NEURON LACTATE SHUTTLE CONTRIBUTES TO PAC1-INDUCED LONG-TERM MECHANICAL ALLODYNIA2017

    • Author(s)
      Kambe Y., Yokai M., Takasaki, I., Kurihara T., Miyata, A
    • Organizer
      13th international symposium on VIP, PACAP and related peptides.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PACAP 誘発疼痛様行動における脊髄アストロサイト-ニューロン乳酸シャトル(ANLS) の関与2017

    • Author(s)
      栗原 崇, 神戸悠輝, 用皆正文, 高﨑一朗, 宮田篤郎.
    • Organizer
      生理学研究所 研究会 「痛みを中心とする有害状況適応の神経戦略バイオロジー」 (痛み研究会2017)
    • Related Report
      2017 Annual Research Report
  • [Book] ベッドサイドの薬理学2018

    • Author(s)
      笹栗俊之、宮田篤郎 編
    • Total Pages
      432
    • Publisher
      丸善出版
    • ISBN
      9784621302743
    • Related Report
      2017 Annual Research Report
  • [Remarks] 鹿児島大学大学院医歯学総合研究科生体情報薬理学

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 鹿児島大学大学院医歯学総合研究科生体情報薬理学分野

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] PAC1受容体拮抗薬を用いた鎮痛薬2017

    • Inventor(s)
      栗原 崇、高崎一朗、豊岡尚樹、合田浩明
    • Industrial Property Rights Holder
      栗原 崇、高崎一朗、豊岡尚樹、合田浩明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-186447
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi