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Development of a all modality treatment planning system which can perform dose estimations for every external radiation therapy

Research Project

Project/Area Number 16K15343
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kumada Hiroaki  筑波大学, 医学医療系, 准教授 (30354913)

Co-Investigator(Kenkyū-buntansha) 米内 俊祐  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 加速器工学部, チームリーダー(定常) (00415431)
高田 健太  筑波大学, 医学医療系, 助教 (10640782)
石川 仁  筑波大学, 医学医療系, 教授 (70344918)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords治療計画 / 放射線治療 / モンテカルロ計算 / 線量評価 / X線治療 / 粒子線治療 / ホウ素中性子捕捉療法 / モンテカルロ / 放射線外照射 / 中性子捕捉療法 / 炭素線 / X線 / 陽子線 / 放射線治療技術学 / 治療計画装置 / モンテカルロ法
Outline of Final Research Achievements

The aim of this study is to develop elemental technologies for treatment planning system applicable to every type of radiotherapy. In the study, we utilized “Tsukuba-Plan” which employs a multi-modal Monte Carlo code; PHITS. The PHITS allows implementing behaviors for every radiation. We created PHITS calculation definitions for several radiotherapy devices installed in University of Tsukuba Hospital as X-ray treatment device, proton therapy and BNCT. For carbon therapy, we made a definition for experimental port of NIRS. The definitions were installed in Tsukuba-Plan. And several phantom experiments performed in each facility were simulated with the Tsukuba-Plan. In verification, the calculation results determined by the Tsukuba-Plan were compared with the experimental values, respectively. The calculations were in good agreement with the experimental values. The results demonstrated that the Tsukuba-Plan allows performing dose estimations for several radiotherapies.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (15 results) (of which Int'l Joint Research: 9 results,  Invited: 7 results)

  • [Journal Article] Development of LINAC-Base Neutron Source for Boron Neutron Capture Therapy in University of Tsukuba2018

    • Author(s)
      H. Kumada F. Naito, K. Hasegawa, H. Kobayashi, T. Kurihara, K. Takada, T. Onishi, H. Sakurai, A. Matsumura, T. Sakae
    • Journal Title

      Plasma and Fusion Research

      Volume: 13 Pages: 1-6

    • NAID

      120007128335

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution.2018

    • Author(s)
      Sato T, Masunaga S, Kumada H, Hamada N.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-017-18871-0

    • NAID

      120007134502

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Validation of the physical and rbe-weighted dose estimator based on phits coupled with a microdosimetric kinetic model for proton therapy2018

    • Author(s)
      Takada K, Sato T, Kumada H, Koketsu J, Takei H, Sakurai H, Sakae T
    • Journal Title

      J Radiat Res

      Volume: 59 Issue: 1 Pages: 91-99

    • DOI

      10.1093/jrr/rrx057

    • NAID

      120007134553

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a multimodal Monte Carlo based treatment planning system, Radiation Protection Dosimetry2017

    • Author(s)
      Kumada H, Takada K, Sakurai Y, Suzuki M, Takata T, Sakurai H, Matsumura A, Sakae T
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 26 Issue: 1-4 Pages: 1-5

    • DOI

      10.1093/rpd/ncx218

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutron spectral fluence measurements using a Bonner sphere spectrometer in the development of the iBNCT accelerator-based neutron source2017

    • Author(s)
      Masuda Akihiko、Matsumoto Tetsuro、Takada Kenta、Onishi Takahiro、Kotaki Kohei、Sugimoto Hidenori、Kumada Hiroaki、Harano Hideki、Sakae Takeji
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 127 Pages: 47-51

    • DOI

      10.1016/j.apradiso.2017.05.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホウ素中性子捕捉療法:BNCTの確立に向けた研究開発2017

    • Author(s)
      熊田博明
    • Journal Title

      放射線と産業

      Volume: 142 Pages: 17-21

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中性子源の利用-医学利用(ホウ素中性子捕捉療法)-2017

    • Author(s)
      熊田博明, 榮武二, 高田健太, 櫻井英幸, 松村明
    • Journal Title

      加速器

      Volume: 13(4) Pages: 253-258

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of Radiation-Resistant Real-Time Neutron Monitor for Accelerator-Based BNCT2016

    • Author(s)
      T. Nakamura, K. Sakasai, H. Nakashima, K. Takamiya, H. Kumada
    • Journal Title

      Journal of Radiation Protection and Research

      Volume: 41 (2) Issue: 2 Pages: 105-109

    • DOI

      10.14407/jrpr.2016.41.2.105

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Monte Carlo based real-time treatment planning system with fast calculation algorithm for boron neutron capture therapy2016

    • Author(s)
      Takada K, Kumada H, Liem PH, Sakurai H, Sakae T.
    • Journal Title

      Phys Med

      Volume: 32 Issue: 12 Pages: 1846-1851

    • DOI

      10.1016/j.ejmp.2016.11.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions2016

    • Author(s)
      M. Ishikawa, T. Yamamoto, A. Matsumura, J. Hiratsuka, S. Miyatake, I. Kato, Y. Sakurai, H. Kumada, S.J.Shrestha, K.Ono
    • Journal Title

      Radiation Oncology

      Volume: 11 (105) Issue: 1 Pages: 1-10

    • DOI

      10.1186/s13014-016-0680-0

    • NAID

      120007129420

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of fluoride-18-labeled boronophenylalanine-positron emission tomography imaging for the assessment of boron neutron capture therapy in patients with recurrent head and neck squamous cell carcinoma2016

    • Author(s)
      T.Aihara, J.Hiratsuka, N.Fukumitsu, H.Ishikawa, N.Morita, H.Kumada, N.Kamitani, K.Ohnishi, M.Suzuki, H.Sakurai, T.Harada
    • Journal Title

      Otolaryngology

      Volume: 6 (6) Issue: 06 Pages: 1-5

    • DOI

      10.4172/2161-119x.1000277

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 小型加速器中性子源の医学応用2017

    • Author(s)
      熊田博明
    • Organizer
      日本物理学会第72回年次大会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 筑波大学のBNCT 用加速器ベース 小型中性子源の開発状況2017

    • Author(s)
      熊田博明
    • Organizer
      第10回 Quantum Medicine 研究会
    • Place of Presentation
      茨城大学(茨城県水戸市)
    • Year and Date
      2017-02-12
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Development status of the linac-based BNCT treatment facility in University of Tsukuba2017

    • Author(s)
      Hiroaki Kumada
    • Organizer
      The 2nd Academic Conference for Taiwan Society of Neutron Capture Therapy (TSNCT)
    • Place of Presentation
      台北英民病院(台湾)
    • Year and Date
      2017-01-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 3Dプリンター技術と治療計画システムを組み合わせた新しいBNCT用患者固定治具の製作手法の開発2017

    • Author(s)
      熊田博明、水野佳久、栗原文夫、林田大造、中村和洋、高田健太、櫻井英幸、松村明、榮武二
    • Organizer
      医学物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a multi-modal Monte-Carlo based treatment planning system2017

    • Author(s)
      H. Kumada, K. Takada, H. Sakurai, A. Matsumura, T. Sakae
    • Organizer
      NEUDOS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development for accelerator-based BNCT devices in University of Tsukuba2017

    • Author(s)
      H. Kumada
    • Organizer
      International Workshop for neutron capture therapy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] development and use of treatment planning software for clinical BNCT2017

    • Author(s)
      H. Kumada
    • Organizer
      Symposium: Current Clinical Status of Boron Neutron Capture Therapy and Paths to the Future
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Verification of dose estimation for Monte-Carlo based treatment planning system for boron neutron capture therapy2017

    • Author(s)
      H. Kumada, K. Takada, T. Aihara, A. Matsumura, H. Sakurai, T. Sakae
    • Organizer
      MCMA2017 (International Conference on Monte Carlo for Medical Application)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application expansion of the Monte-Carlo based treatment planning system for BNCT to particle radiotherapy and X-ray therapy2017

    • Author(s)
      H. Kumada, K. Takada, T. Aihara, A. Matsumura, H. Sakurai, T. Sakae
    • Organizer
      MCMA2017 (International Conference on Monte Carlo for Medical Application)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fundamental Study for Practical Application of Radiotherapy Treatment Planning System Capable of Evaluating Neutron Dose Generated by Various Radiotherapy2017

    • Author(s)
      K. Takada, H. Kumada, J. Kouketsu, S.Tobita, T. Terunuma, H. Sakura, T. Sakae
    • Organizer
      MCMA2017 (International Conference on Monte Carlo for Medical Application)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ホウ素中性子捕捉療法:BNCTの 確立に向けた研究開発2016

    • Author(s)
      熊田博明
    • Organizer
      第16回放射線プロセスシンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-11-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A new production method for patient fixing implement by combination with a three-dimensional printing technique and treatment planning system2016

    • Author(s)
      H. Kumada, Y. Mizuno, F. Kurihara, T. Hayashida, K. Nakamura, K. Takada, T. Aihara, H. Sakurai, A. Matsumura, T. Sakae
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      ミズーリ大学(米国)
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computational dosimetry by Monte Carlo calculation for several BNCT facilities with new treatment planning system "Tsukuba-Plan"2016

    • Author(s)
      Kenta Takada, Hiroaki Kumada, Yoshinori Sakurai, Takushi Takata, Minoru Suzuki, Hideyuki Sakurai, Akira Matsumura, Takeji Sakae
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      ミズーリ大学(米国)
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] BNCTにおける治療計画・線量評価 ・QA/QCの標準化について2016

    • Author(s)
      熊田博明、櫻井良憲、田中浩基
    • Organizer
      日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-08-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 筑波大学の加速器ベースBNCT用 治療装置の開発状況2016

    • Author(s)
      熊田博明
    • Organizer
      東京RBC講演会
    • Place of Presentation
      リコッティ(茨城県東海村)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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